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Shared Resource to Investigate Cellular Metabolism

Award Number: P20GM103625
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2012
PERIOD OF PERFORMANCE END DATE: 04/30/2023

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Shared Resource to Investigate Cellular Metabolism - Phase II PROJECT SUMMARY/ABSTRACT Addressing infectious disease in a therapeutically relevant fashion requires an understanding of both the microbial virulence factors that contribute to the disease process and the manner in which these factors impact the host immunological and inflammatory response. Achieving this will provide an opportunity to develop novel strategies to influence the pathogen and/or host response in favor of the host, thereby providing a perfect opportunity for clinically relevant translational research. Thus, achieving this understanding continues to be the overall goal of our Center for Microbial Pathogenesis and Host Inflammatory Responses. The key element to accomplishing this is to assemble a critical mass of investigators, each under the mentorship of established senior faculty, whose research is consistent with this underlying scientific theme and the overall goals of our Center. The underlying hypothesis that ties these investigators together is that targeting diverse microbial pathogens in the context of their impact on immunological and inflammatory responses in their common human host will optimize opportunities for the elucidation of common themes with respect to the host response and its adverse consequences on the disease process. To this end, this application brings together as Project Leaders four investigators who focus on diverse microbial pathogens from the point of view of both the pathogens themselves and their impact on host inflammatory responses. To support these investigators, and to build a pipeline of new investigators whose research is consistent with our underlying scientific theme, we propose to provide an integrated and highly interactive faculty development plan for all Center investigators that leverages the resources developed during Phase I to enable our Phase II Project Leaders and other Center investigators to establish independently-funded research careers in an area consistent with this underlying theme (Aim 1); to utilize the Administrative and Scientific Development (Core A) and Research and Technical Advancement (Core B) cores developed during Phase I to continue to promote the scientific development of Center investigators and enhance the overall research infrastructure on the host campuses (Aim 2); and to build on the success of our Phase I efforts to recruit additional investigators whose research is consistent with the underlying scientific theme and promote the development of collaborative, synergistic research relationships among Center investigators (Aim 3). This will allow us to build on the success of Phase I Project Leaders to establish a self-sustaining Center for Microbial Pathogenesis and Host Inflammatory Responses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$195,603 )
2024	2021	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	10	10/17/2023	NON-COMPETING CONTINUATION	-$10,031
2024	2021	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	10	10/17/2023	SUPPLEMENT FOR EXPANSION	-$185,572
														Subtotal = -$195,603

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	10	10/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	10	3/29/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	10	3/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,412,918 )
2021	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	10	8/19/2021	SUPPLEMENT FOR EXPANSION	$185,572
2021	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	10	5/21/2021	NON-COMPETING CONTINUATION	$2,227,346
														Subtotal = $2,412,918

Issue Date FY: 2020 ( Subtotal = $2,530,445 )
2020	2020	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	9	8/24/2020	SUPPLEMENT FOR EXPANSION	$303,099
2020	2020	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	9	7/22/2020	NON-COMPETING CONTINUATION	$2,227,346
2020	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	8	3/2/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,530,445

Issue Date FY: 2019 ( Subtotal = $2,227,346 )
2019	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	8	8/16/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	8	5/3/2019	NON-COMPETING CONTINUATION	$2,227,346
2019	2018	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	7	2/14/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,227,346

Issue Date FY: 2018 ( Subtotal = $2,227,346 )
2018	2018	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	7	5/2/2018	NON-COMPETING CONTINUATION	$2,227,346
2018	2018	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	7	7/18/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,227,346

Issue Date FY: 2017 ( Subtotal = $2,153,846 )
2017	2017	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	003	6	5/1/2017	COMPETING CONTINUATION	$2,153,846
2017	2017	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	005	6	9/5/2017	COMPETING CONTINUATION	$71,416
2017	2016	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	5	1/27/2017	EXTENSION WITH OR WITHOUT FUNDS	$25,499
2017	2016	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	004	5	9/5/2017	EXTENSION WITH OR WITHOUT FUNDS	-$71,416
2017	2016	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	5	4/28/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
2017	2015	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	4	1/27/2017	NON-COMPETING CONTINUATION	-$25,499
														Subtotal = $2,153,846

Issue Date FY: 2016 ( Subtotal = $2,012,133 )
2016	2016	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST, M S 545	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	5	4/12/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,012,133
														Subtotal = $2,012,133

Issue Date FY: 2015 ( Subtotal = $2,012,133 )
2015	2015	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST, M S 545	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	4	5/6/2015	NON-COMPETING CONTINUATION	$2,012,133
														Subtotal = $2,012,133

Issue Date FY: 2014 ( Subtotal = $2,012,133 )
2014	2014	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST, M S 545	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	3	4/24/2014	NON-COMPETING CONTINUATION	$2,012,133
														Subtotal = $2,012,133

Issue Date FY: 2013 ( Subtotal = $1,941,709 )
2013	2013	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST, M S 545	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	2	5/31/2013	NON-COMPETING CONTINUATION	$130,789
2013	2013	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST, M S 545	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	2	4/15/2013	NON-COMPETING CONTINUATION	$1,810,920
														Subtotal = $1,941,709

Issue Date FY: 2012 ( Subtotal = $1,982,756 )
2012	2012	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST, M S 545	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	1	8/6/2012	NEW	$1,982,756
														Subtotal = $1,982,756

Grand Total All Awards = $21,317,162

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Shared Resource to Investigate Cellular Metabolism

Award Number: P20GM103625

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2012

PERIOD OF PERFORMANCE END DATE: 04/30/2023

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