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Multimodal Imaging of Neuropsychiatric Disorders (MIND): Mechanisms &

Award Number: P20GM103472
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/08/2008
PERIOD OF PERFORMANCE END DATE: 04/30/2019

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Multimodal Imaging of Neuropsychiatric Disorders (MIND): Mechanisms & - DESCRIPTION (provided by applicant): This Phase II COBRE project is a natural extension of our Phase I COBRE on multimodal neuroimaging in schizophrenia. In the next evolution we will build on our success in Phase I to include a wider range of disease categories making the overarching theme of the Phase II COBRE the use of multimodal neuroimaging to better understand the neural mechanisms of psychosis and mood disorders. The Mind Research Network (MRN) houses an Elekta MEG System, a high density EEG lab, and a 3T Siemens Trio MRl scanner. Additional resources include a centralized neuroinformatics system, a strong IT management plan, and state-of-the-art image analysis tools. The Phase II COBRE will provide support to five outstanding junior investigators through the assistance of strong senior mentors. The five projects each focus on distinct, but related, aspects of psychosis and mood disorders. Project 1 will utilize advanced data fusion methods to evaluate the ability of multimodal brain imaging data to differentiate patient groups and to push beyond discrete diagnostic categories by identifying individuals in intermediate positions on the continuum. Project 2 is an expansion of the pilot genetic program from the Phase I to evaluate the shared and unique aspects of genetic influence on brain structural networks using advanced multivariate methods. Project 3 will focus on the lens of social cognition and evaluate functional networks in patients while perceiving facial and vocal emotions. The ability of both structural and functional networks to differentiate groups and predict outcomes will be evaluated. Project 4 will focus on auditory hallucinations using MEG and fMRI. Evaluation of the ability to predict hallucinations from the imaging data as well as the impact of transcranial direct current stimulation (tDCS) on the identified brain networks will be investigated. And finally, Project 5 will use a longitudinal desin to study brain networks related to major depression and relapse after treatment with electro-convulsive therapy (ECT). We will continue with the cores established during the Phase I project including administration, clinical assessment, and mentoring (ACAM), multimodal data acquisition (MDA), algorithm and data analysis (ADA), and biostatistics and neuro-informatics (BNI). These cores have begun to serve MRN and the greater community, as well as other institutions including extension collaborations with IDeA funded projects in New Mexico and other states. A highly successful pilot project program will be continued. We believe this Phase II COBRE is extremely well-positioned to establish New Mexico as one of the premier brain imaging sites. We include an extensive educational, mentoring, and faculty development program to carefully mentor and establish junior investigators as independently funded investigators, thus fulfilling the ultimate goals of the COBRE program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $231,769 )
2022	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	001	10	9/28/2022	NON-COMPETING CONTINUATION	-$62,827
2022	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	000	10	9/26/2022	NON-COMPETING CONTINUATION	$294,596
														Subtotal = $231,769

Issue Date FY: 2020 ( Subtotal = -$294,596 )
2020	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	000	10	11/21/2019	NON-COMPETING CONTINUATION	-$294,596
														Subtotal = -$294,596

Issue Date FY: 2017 ( Subtotal = $2,369,326 )
2017	2017	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	003	10	7/12/2017	NON-COMPETING CONTINUATION	$2,369,326
2017	2016	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	002	9	6/1/2017	EXTENSION WITH OR WITHOUT FUNDS	$1,892,102
2017	2015	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	001	8	6/1/2017	NON-COMPETING CONTINUATION	-$1,892,102
2017	2012	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Biomedical Research and Research Training	000	5	5/11/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $2,369,326

Issue Date FY: 2016 ( Subtotal = $2,375,198 )
2016	2016	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	9	5/19/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,375,198
														Subtotal = $2,375,198

Issue Date FY: 2015 ( Subtotal = $2,402,180 )
2015	2015	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	8	7/9/2015	NON-COMPETING CONTINUATION	$2,402,180
														Subtotal = $2,402,180

Issue Date FY: 2014 ( Subtotal = $2,418,292 )
2014	2014	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	7	5/21/2014	NON-COMPETING CONTINUATION	$2,418,292
														Subtotal = $2,418,292

Issue Date FY: 2013 ( Subtotal = $2,473,512 )
2013	2013	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	001	6	7/29/2013	COMPETING CONTINUATION	$2,473,512
2013	2012	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	5	7/26/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $2,473,512

Issue Date FY: 2012 ( Subtotal = $2,271,690 )
2012	2012	THE MIND RESEARCH NETWORK	1101 YALE BOULEVARD NORTHEAST	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Biomedical Research and Research Training	000	5	6/15/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,271,690
														Subtotal = $2,271,690

Grand Total All Awards = $14,247,371

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Multimodal Imaging of Neuropsychiatric Disorders (MIND): Mechanisms &

Award Number: P20GM103472

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/08/2008

PERIOD OF PERFORMANCE END DATE: 04/30/2019

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