Tuesday, October 15, 2024 10/15/2024

Vermont INBRE Administrative Supplement 2024 AWD 118

Award Number: P20GM103449
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Over the last two decades there has been a dramatic increase in the number and expansion in the geographic range of Lyme disease cases. These are likely caused by increasing temperature's effect on populations of the Lyme disease vector, the blacklegged tick. With expected continued warming and climate change, the geographic range of the blacklegged tick and Lyme disease should continue to change. We need better tools to map the current range of blacklegged tick populations and to forecast future range shifts and year-to-year variations. The development of these tools is hampered by the fact that blacklegged ticks respond to stochastic extreme weather events, while models of tick populations are based on deterministic climate averages. In Aim 1 we will first address this limitation by conducting a series of observations in the field to understand how weather variation and extremes affect life history processes of the blacklegged tick. We will use two types of tick enclosures to monitor tick host-seeking behavior and tick survival. At the same time, we will track temperature and relative humidity in the leaf litter, which is the microclimate that tick's experience. In Aim 2 we will develop a novel tick population model that will be encoded with the results of Aim 1. It will predict how tick populations respond to continuous weather fluctuations rather than just mean climate. This new tool has a stochastic structure so that it can predict how rare events could lead to population bottlenecks or local extinctions. Such a structure is typically very computationally intensive, but we have developed a novel approach which can switch between computationally-intensive, exact population modeling and a computationally-cheap average approximation when necessary. This model will be validated by hindcasting to existing blacklegged and Lyme disease distribution data, and then used to predict future distribution with climate change projections. The code for the model will be shared, as the approach is useful to modeling other arthropod vectors as well.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $3,999,996 )
2024	2024	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	002	23	5/24/2024	SUPPLEMENT FOR EXPANSION	$180,345
2024	2024	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	001	23	5/23/2024	NON-COMPETING CONTINUATION	$3,819,651
2024	2023	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	22	1/3/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,999,996

Issue Date FY: 2023 ( Subtotal = $3,820,251 )
2023	2023	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	001	22	5/25/2023	NON-COMPETING CONTINUATION	$3,820,251
2023	2022	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	21	12/6/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,820,251

Issue Date FY: 2022 ( Subtotal = $3,820,963 )
2022	2022	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	003	21	7/1/2022	NON-COMPETING CONTINUATION	$3,820,963
2022	2021	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	001	20	12/7/2021	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	20	10/26/2021	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	002	20	2/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,820,963

Issue Date FY: 2021 ( Subtotal = $3,822,428 )
2021	2021	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	003	20	7/19/2021	NON-COMPETING CONTINUATION	$3,822,428
2021	2020	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	002	19	11/13/2020	COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	001	19	10/20/2020	COMPETING CONTINUATION	$636,568
2021	2019	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	18	10/20/2020	NON-COMPETING CONTINUATION	-$636,568
														Subtotal = $3,822,428

Issue Date FY: 2020 ( Subtotal = $4,274,086 )
2020	2020	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	003	19	7/13/2020	COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	002	19	5/28/2020	COMPETING CONTINUATION	$4,111,856
2020	2020	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	004	19	9/7/2020	SUPPLEMENT FOR EXPANSION	$162,230
2020	2019	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	001	18	5/26/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	18	11/18/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,274,086

Issue Date FY: 2019 ( Subtotal = $3,468,028 )
2019	2019	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	001	18	6/20/2019	NON-COMPETING CONTINUATION	$3,468,028
2019	2018	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	17	11/29/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,468,028

Issue Date FY: 2018 ( Subtotal = $3,463,028 )
2018	2018	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	17	7/10/2018	NON-COMPETING CONTINUATION	$3,463,028
														Subtotal = $3,463,028

Issue Date FY: 2017 ( Subtotal = $3,489,860 )
2017	2017	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT ST	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	16	6/29/2017	NON-COMPETING CONTINUATION	$3,489,860
														Subtotal = $3,489,860

Issue Date FY: 2016 ( Subtotal = $3,567,181 )
2016	2016	UNIVERSITY OF VERMONT	223 WATERMAN BUILDING	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	15	6/21/2016	NON-COMPETING CONTINUATION	$3,497,390
2016	2016	UNIVERSITY OF VERMONT	223 WATERMAN BUILDING	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	001	15	9/1/2016	SUPPLEMENT FOR EXPANSION	$69,791
														Subtotal = $3,567,181

Issue Date FY: 2015 ( Subtotal = $3,866,876 )
2015	2015	UNIVERSITY OF VERMONT	223 WATERMAN BUILDING	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	14	5/15/2015	COMPETING CONTINUATION	$3,866,876
														Subtotal = $3,866,876

Issue Date FY: 2014 ( Subtotal = $3,073,807 )
2014	2014	UNIVERSITY OF VERMONT	223 WATERMAN BUILDING	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	13	5/28/2014	NON-COMPETING CONTINUATION	$3,073,807
														Subtotal = $3,073,807

Issue Date FY: 2013 ( Subtotal = $2,996,505 )
2013	2013	UNIVERSITY OF VERMONT	223 WATERMAN BUILDING	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	12	6/8/2013	NON-COMPETING CONTINUATION	$2,996,505
														Subtotal = $2,996,505

Issue Date FY: 2012 ( Subtotal = $3,163,270 )
2012	2012	UNIVERSITY OF VERMONT	223 WATERMAN BUILDING	BURLINGTON	VT	05405	CHITTENDEN	USA	Biomedical Research and Research Training	000	11	5/17/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$3,163,270
														Subtotal = $3,163,270

Grand Total All Awards = $46,826,279

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Vermont INBRE Administrative Supplement 2024 AWD 118

Award Number: P20GM103449

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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