Saturday, November 23, 2024 11/23/2024

Delaware INBRE

Award Number: P20GM103446
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Ovarian cancer (OVC) is the deadliest gynecologic cancer and the fifth leading cause of cancer-related death among US women. A critical limitation in fighting OVC is the inability to detect OVC early (stages I & II). Detection at early stages improves five-year survival to ~95% compared to ~57% overall. The five-year survival further drops to ~36% for black women. Currently, no reliable diagnostic markers are available that identify OVC early and accurately. We utilize female chickens (hens) as a model to identify early and accurate diagnostic biomarkers for OVC. Chickens (unlike mice) develop OVC spontaneously, just like humans. Moreover, disease progression and disease staging parallels human OVC. Further, total number of ovulation events (a risk factor, if high) and age of onset (menopause) are also similar across both species. The overarching long-term goal of this research is to design and validate a diagnostic test similar to a mammogram or a pap smear that can be routinely performed to identify OVC before it can be clinically identified. Based on our preliminary data, this proposal seeks to identify and validate the potential role of lipid metabolites as potential diagnostic biomarkers of OVC. In this proposal, we will utilize specific-pathogen free hens as an animal model. These hens develop OVC spontaneously (similar to humans) with ~10-30% penetrance by 3.5 years of age. Based on our pilot studies, we will perform non-biased metabolomic analysis on longitudinally harvested plasma samples using the Sciex 6500+ quadropule ion trap (QTrap) in conjunction with the C18 liquid chromatography-tandem mass spectrometry (LC-MS/MS) Multiple Reaction Monitoring (MRM) method for detecting ~550+ annotated metabolites. Further, we will perform pre-clinical metabolomic validation on plasma samples obtained directly from untreated patients, patients with benign disease presentation, and age-matched controls. Such comprehensive metabolite profiling especially for lipid metabolites as early and accurate diagnostic biomarkers in human ovarian cancer lays the groundwork for large-scale validation in patients, helping fulfill a critical need in the ovarian cancer precision prevention landscape.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $5,991,046 )
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	007	23	4/18/2024	SUPPLEMENT FOR EXPANSION	$208,400
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	006	23	4/1/2024	SUPPLEMENT FOR EXPANSION	$4,476,746
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	009	23	8/12/2024	SUPPLEMENT FOR EXPANSION	$846,312
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	010	23	9/10/2024	SUPPLEMENT FOR EXPANSION	$279,134
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	008	23	6/28/2024	SUPPLEMENT FOR EXPANSION	$180,454
2024	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	004	23	4/1/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	23	4/1/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	23	4/1/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	23	4/1/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	005	23	4/1/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	23	1/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,991,046

Issue Date FY: 2023 ( Subtotal = $5,169,466 )
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	004	23	7/20/2023	SUPPLEMENT FOR EXPANSION	$309,285
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	23	5/26/2023	SUPPLEMENT FOR EXPANSION	$176,546
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	23	3/28/2023	NON-COMPETING CONTINUATION	$3,652,387
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	005	23	8/14/2023	SUPPLEMENT FOR EXPANSION	$783,500
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	23	6/30/2023	SUPPLEMENT FOR EXPANSION	$247,748
2023	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	22	1/12/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,169,466

Issue Date FY: 2022 ( Subtotal = $4,233,450 )
2022	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	004	22	4/27/2022	NON-COMPETING CONTINUATION	$3,717,654
2022	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	007	22	9/29/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	005	22	6/14/2022	SUPPLEMENT FOR EXPANSION	$515,000
2022	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	21	3/28/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	21	2/16/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	21	2/16/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	21	10/28/2021	NON-COMPETING CONTINUATION	$0
2022	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	006	18	9/23/2022	NON-COMPETING CONTINUATION	$796
														Subtotal = $4,233,450

Issue Date FY: 2021 ( Subtotal = $4,648,878 )
2021	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	21	8/12/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	21	7/14/2021	SUPPLEMENT FOR EXPANSION	$360,717
2021	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	21	4/30/2021	NON-COMPETING CONTINUATION	$4,053,243
2021	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	20	12/1/2020	SUPPLEMENT FOR EXPANSION	$234,918
														Subtotal = $4,648,878

Issue Date FY: 2020 ( Subtotal = $3,869,102 )
2020	2020	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	004	20	8/26/2020	SUPPLEMENT FOR EXPANSION	$136,006
2020	2020	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	20	5/12/2020	NON-COMPETING CONTINUATION	$3,733,096
2020	2019	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	19	3/14/2020	COMPETING CONTINUATION	$12,551
2020	2019	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	19	3/12/2020	COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	18	3/14/2020	NON-COMPETING CONTINUATION	-$12,551
														Subtotal = $3,869,102

Issue Date FY: 2019 ( Subtotal = $4,181,481 )
2019	2019	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	19	9/3/2019	SUPPLEMENT FOR EXPANSION	$134,087
2019	2019	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	19	5/16/2019	COMPETING CONTINUATION	$4,047,394
2019	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	18	5/14/2019	NON-COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	18	11/1/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,181,481

Issue Date FY: 2018 ( Subtotal = $3,657,195 )
2018	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	18	5/1/2018	NON-COMPETING CONTINUATION	$3,657,195
														Subtotal = $3,657,195

Issue Date FY: 2017 ( Subtotal = $3,641,722 )
2017	2017	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	17	6/20/2017	NON-COMPETING CONTINUATION	$364,172
2017	2017	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	17	4/26/2017	NON-COMPETING CONTINUATION	$3,277,550
														Subtotal = $3,641,722

Issue Date FY: 2016 ( Subtotal = $4,169,755 ) (Continued on the next page)
Grand Total All Awards = $53,474,094

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Delaware INBRE

Award Number: P20GM103446

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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