Thursday, November 21, 2024 11/21/2024

Idaho INBRE Program

Award Number: P20GM103408
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY This Idaho INBRE team science administrative supplement titled, “Establishing a developmentally inspired biomaterial platform to direct stem cell tenogenesis” fits the Idaho INBRE-4 parent grant scientific theme of Cell Signaling. Tendons are strong, collagenous musculoskeletal tissues that transfer mechanical forces from muscle to bone. There is a clinical need for novel regenerative therapies to treat tendon injuries as healing is limited and injuries are associated with long-term loss of function. Three interdisciplinary investigators will work as a team to leverage their individual expertise to design a biomaterial polymer platform to control tenogenesis. Our team includes experts in the areas of tendon development and mesenchymal stem cell (MSC) differentiation (Dr. Schiele – Biomedical Engineering), polymeric hydrogels and biomaterials (Dr. Bernards – Chemical Engineering), and peptide synthesis and organic chemistry (Dr. Waynant – Chemistry). There is a limited understanding of the biochemical and mechanical factors that regulate tenogenesis. Normal embryonic and postnatal tendon development will inform our tenogenic strategy. By leveraging the strengths of the team, we will advance a novel hydrogel platform and knowledge of tenogenic regulators. We will determine the combination of developmentally identified biochemical and mechanical factors that regulate tenogenesis and deliver those factors with a novel biomaterial platform. We hypothesize that developmental factors can be rationally designed into a new class of zwitterionic cross-linked polyampholyte hydrogels to direct MSC into functional tendon cells. The project has two specific aims. Specific Aim 1 develops our team and defines the roles that peptides mimicking the developmentally identified cell-cell junction proteins (cadherin-11 and N- cadherin) and extracellular matrix proteins (fibronection and collagen) have on the induction of stem cell tenogenesis. These signals will be delivered from polyampholyte hydrogels synthesized with novel zwitterionic cross-linkers, which are designed to control the presentation of the desired cell signaling peptides. Specific Aim 2 expands this family of zwitterionic cross-linkers to finetune the mechanical properties of the polyampholyte hydrogels to match specific stages of tendon development. This will determine how the tissue elastic modulus and biochemical signaling together control tenogenesis. To meet Idaho INBRE goals, this team science project also provides opportunities for undergraduate and graduate students to design and test this biomaterial platform, which further enhances the pipeline of well-trained biomedical researchers. The combined results from this team effort will be a family of tunable zwitterionic cross-linker species that are incorporated into polyampholyte hydrogels designed to deliver biochemical and mechanical developmental factors that regulate tenogenesis. We anticipate this will represent a significant breakthrough in modeling and understanding tendon development to guide effective regeneration strategies. These results will be the preliminary data for a collaborative NIH funding application.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $5,303,654 )
2024	2024	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	009	23	7/8/2024	SUPPLEMENT FOR EXPANSION	$250,000
2024	2024	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	010	23	8/27/2024	SUPPLEMENT FOR EXPANSION	$598,537
2024	2024	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	006	23	4/11/2024	SUPPLEMENT FOR EXPANSION	$180,000
2024	2024	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	23	3/27/2024	SUPPLEMENT FOR EXPANSION	$4,206,381
2024	2024	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	008	23	6/17/2024	SUPPLEMENT FOR EXPANSION	$68,736
2024	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	007	23	5/15/2024	NON-COMPETING CONTINUATION	$0
2024	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	23	4/3/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	004	23	4/3/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	003	23	4/3/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	005	23	4/5/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	23	3/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,303,654

Issue Date FY: 2023 ( Subtotal = $4,834,064 )
2023	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	23	3/1/2023	NON-COMPETING CONTINUATION	$3,329,866
2023	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	23	5/8/2023	SUPPLEMENT FOR EXPANSION	$190,515
2023	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	003	23	5/11/2023	NON-COMPETING CONTINUATION	$0
2023	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	005	23	9/15/2023	SUPPLEMENT FOR EXPANSION	$260,792
2023	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	004	23	6/26/2023	SUPPLEMENT FOR EXPANSION	$204,266
2023	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	006	23	9/18/2023	SUPPLEMENT FOR EXPANSION	$848,625
2023	2022	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	22	1/19/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,834,064

Issue Date FY: 2022 ( Subtotal = $3,329,866 )
2022	2022	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	22	6/17/2022	NON-COMPETING CONTINUATION	$332,988
2022	2022	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	22	3/1/2022	NON-COMPETING CONTINUATION	$2,996,878
2022	2021	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	21	3/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,329,866

Issue Date FY: 2021 ( Subtotal = $4,492,524 )
2021	2021	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	21	4/27/2021	NON-COMPETING CONTINUATION	$3,329,866
2021	2021	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	004	21	9/1/2021	SUPPLEMENT FOR EXPANSION	$153,125
2021	2021	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	21	6/1/2021	SUPPLEMENT FOR EXPANSION	$737,106
2021	2021	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	003	21	8/12/2021	SUPPLEMENT FOR EXPANSION	$272,427
2021	2020	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	20	1/12/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,492,524

Issue Date FY: 2020 ( Subtotal = $3,613,851 )
2020	2020	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	004	20	8/3/2020	SUPPLEMENT FOR EXPANSION	$131,975
2020	2020	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	003	20	7/30/2020	NON-COMPETING CONTINUATION	$0
2020	2020	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	20	4/29/2020	NON-COMPETING CONTINUATION	$3,329,866
2020	2020	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	005	20	8/10/2020	SUPPLEMENT FOR EXPANSION	$152,010
2020	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	19	2/23/2020	COMPETING CONTINUATION	$103,103
2020	2018	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	18	2/23/2020	NON-COMPETING CONTINUATION	-$103,103
														Subtotal = $3,613,851

Issue Date FY: 2019 ( Subtotal = $3,933,578 )
2019	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	19	4/5/2019	COMPETING CONTINUATION	$3,769,328
2019	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	19	8/26/2019	COMPETING CONTINUATION	$0
2019	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	19	8/27/2019	SUPPLEMENT FOR EXPANSION	$164,250
														Subtotal = $3,933,578

Issue Date FY: 2018 ( Subtotal = $3,191,459 )
2018	2018	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	18	4/20/2018	NON-COMPETING CONTINUATION	$3,191,459
														Subtotal = $3,191,459

Issue Date FY: 2017 ( Subtotal = $3,215,147 )
2017	2017	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	17	5/2/2017	NON-COMPETING CONTINUATION	$2,893,632
2017	2017	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	003	17	6/20/2017	NON-COMPETING CONTINUATION	$321,515
2017	2014	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	14	4/21/2017	COMPETING CONTINUATION	-$6,159
2017	2013	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	13	4/21/2017	NON-COMPETING CONTINUATION	$6,159
														Subtotal = $3,215,147

Issue Date FY: 2016 ( Subtotal = $3,240,905 )
2016	2016	UNIVERSITY OF IDAHO	Admin Annex Fin Affiars	MOSCOW	ID	83843	LATAH	USA	Biomedical Research and Research Training	000	16	5/19/2016	NON-COMPETING CONTINUATION	$3,240,905
														Subtotal = $3,240,905

Grand Total All Awards = $48,259,260

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Idaho INBRE Program

Award Number: P20GM103408

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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