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Greater Caribbean Center for Ciguatera Research

Award Number: P01ES028949
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Greater Caribbean Center for Ciguatera Research - Of all the poisoning syndromes associated with harmful algal bloom (HAB) toxins, ciguatera poisoning (CP) is the most prevalent globally and is estimated to afflict tens of thousands of people each year, with many cases unreported. CP is primarily caused by the consumption of reef fish (and some invertebrates) contaminated with toxins that originate from species of the (sub)tropical benthic/epiphytic dinoflagellate genera Gambierdiscus and Fukuyoa (hereafter referred to together as Gambierdiscus). CP is predicted to increase in geographic range and frequency in the Greater Caribbean region (GCR) and elsewhere in response to climate change. We established the Greater Caribbean Center for Ciguatera Research (GCCCR) through the Centers of Oceans and Human Health (COHH3) program to study the anticipated intensification of CP in the GCR due to warming sea surface temperatures and reef degradation associated with climate change. The major goals of GCCCR in COHH3 are to: 1) examine the role climate change may play in the geographic and temporal expansion of ciguatera poisoning (CP) into more temperate latitudes (Research Project 1); 2) obtain a better understanding of the toxic metabolites produced by certain Gambierdiscus strains, and the subsequent transfer and biotransformation of these compounds into coastal/reef food webs (Research Project 2); 3) study the genotoxicity and impacts on cellular metabolism caused by these toxins upon exposure (Research Project 3), in order to 4) better protect and treat people from this malady by translating the above scientific findings into risk-based outputs for engagement and education activities for the community in the Greater Caribbean Region (Community Engagement Core). While the GCCCR has been productive to date, Hurricane Ian severely hindered progress, particularly in Florida and specifically at FGCU. Hurricane Ian made landfall in southwest Florida (near FGCU) on September 28, 2022. The 10’+ storm surge caused significant damage to our coasts, including the FGCU Vester Field Station in Bonita Springs, Florida. This damage has rendered Vester inoperable to date. In the aftermath of Hurricane Ian, PD Parsons had to spend considerable time and effort coordinating clean-up and repairs. Additionally, adjusting our research activities has been challenging (no dock access; damaged boats; inaccessible sampling sites). While repairs are underway, we have lost considerable time (and resources), hindering our progress and ability to complete our remaining tasks in the COHH3 project of GCCCR. Herein, we are requesting an Administrative Supplement to address the infrastructure impacts including replacement of research resources, one lost boat, and financial assistance with building repairs and renovations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,431,989 )
2024	2024	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	001	5	5/9/2024	SUPPLEMENT FOR EXPANSION	$458,788
2024	2024	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	002	5	5/10/2024	SUPPLEMENT FOR EXPANSION	$973,201
2024	2023	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	000	5	5/9/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,431,989

Issue Date FY: 2023 ( Subtotal = $458,788 )
2023	2023	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	002	5	8/25/2023	NON-COMPETING CONTINUATION	$458,788
2023	2021	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	001	4	8/24/2023	NON-COMPETING CONTINUATION	$0
2023	2021	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	000	4	6/29/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $458,788

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	000	4	7/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $462,980 )
2021	2021	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	000	4	7/2/2021	NON-COMPETING CONTINUATION	$462,980
														Subtotal = $462,980

Issue Date FY: 2020 ( Subtotal = $477,071 )
2020	2020	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	000	3	7/1/2020	NON-COMPETING CONTINUATION	$477,071
														Subtotal = $477,071

Issue Date FY: 2019 ( Subtotal = $471,042 )
2019	2019	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	001	2	7/17/2019	NON-COMPETING CONTINUATION	$471,042
2019	2018	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	000	1	4/1/2019	NEW	$0
														Subtotal = $471,042

Issue Date FY: 2018 ( Subtotal = $493,091 )
2018	2018	FLORIDA GULF COAST UNIVERSITY	10501 FGCU BLVD S	FORT MYERS	FL	33965	LEE	USA	Environmental Health	000	1	9/20/2018	NEW	$493,091
														Subtotal = $493,091

Grand Total All Awards = $3,794,961

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Greater Caribbean Center for Ciguatera Research

Award Number: P01ES028949

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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