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Woods Hole Center for Oceans and Human Health

Award Number: P01ES028938
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Woods Hole Center for Oceans and Human Health - The Woods Hole Center for Oceans and Human Health (WHCOHH) will comprise a strong and integrated set of research projects using novel in situ sampling technologies and modeling approaches building on prior research to address how environmental factors influence harmful algal bloom (HAB) dynamics and human exposure to HAB toxins, a serious and global human health threat. The overall objective is to protect public health through enhanced understanding of how oceanic processes affect the intensity and distribution of toxin producing HABs and to understand the potential health risks from exposure even to low levels of their potent neurotoxins, especially during susceptible stages of life. The Center will focus on two key HAB taxa: Alexandrium catenella, which produces the saxitoxins responsible for paralytic shellfish poisoning (PSP), and Pseudo-nitzschia spp., which produce domoic acid responsible for amnesic shellfish poisoning (ASP) syndrome, both are expanding geographically. Novel, targeted, efficient, and data-rich sampling approaches developed by the applicants and applied in situ in natural settings have revealed new controls of A. catenella population dynamics and have identified possible new environmental links regarding toxic Pseudo-nitzschia species. Project 1 will examine further the physiological and environmental variables affecting these HABs, which may underlie population adaptation in different habitats and different environmental regimes. Project 2 will incorporate these new and fundamental insights on bloom regulation into coupled population models to predict HAB events, a key step toward being able to quantify future risks from this recurrent public health threat. In biomedical studies with the zebrafish model, Project 3 has identified myelination in the developing brain as a target of domoic acid. They will use transgenic zebrafish and single-cell RNA-sequencing to identify the cell-specific mechanisms underlying effects of domoic acid, saxitoxin, and the cyanotoxin anatoxin-a in zebrafish embryos in vivo and will use human iPSC-derived 3D brain systems in vitro to elucidate toxin effects on neural and glial cell differentiation in human cells. Studies also will determine whether prior exposure to ubiquitous persistent organic pollutants may modify effects of subsequent exposure to saxitoxin and domoic acid. All projects will collaborate to link oceanic processes to human exposure, helping to define the exposure of susceptible human subpopulations. The Community Engagement Core will facilitate integration of the research with education and engagement of resource managers and other stakeholders. We also will improve awareness of emerging HAB issues for the public health community and develop new educational materials and interactive activities for K-12 classrooms, and for health care providers. An Administrative Core will encourage open discussion of planning, integration, and communication, and provide rigorous evaluation of progress in all aspects of the program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,070,188 )
2025	2025	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	003	7	6/23/2025	NON-COMPETING CONTINUATION	$535,094
2025	2025	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	001	5	10/17/2024	SUPPLEMENT FOR EXPANSION	$535,094
2025	2024	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	002	6	10/17/2024	COMPETING CONTINUATION	$215,595
2025	2022	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	001	5	10/17/2024	SUPPLEMENT FOR EXPANSION	-$18,879
2025	2022	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	000	5	10/17/2024	NON-COMPETING CONTINUATION	-$196,715
														Subtotal = $1,070,188

Issue Date FY: 2024 ( Subtotal = $584,932 )
2024	2024	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	001	6	3/8/2024	COMPETING CONTINUATION	$584,932
2024	2024	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	002	6	3/27/2024	COMPETING CONTINUATION	$0
2024	2022	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	000	5	2/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $584,932

Issue Date FY: 2022 ( Subtotal = $608,324 )
2022	2022	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	001	5	6/28/2022	SUPPLEMENT FOR EXPANSION	$53,270
2022	2022	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	000	5	6/27/2022	NON-COMPETING CONTINUATION	$555,054
														Subtotal = $608,324

Issue Date FY: 2021 ( Subtotal = $670,341 )
2021	2021	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	002	4	6/18/2021	NON-COMPETING CONTINUATION	$555,054
2021	2021	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	000	3	3/18/2021	SUPPLEMENT FOR EXPANSION	$30,662
2021	2021	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	003	4	6/21/2021	SUPPLEMENT FOR EXPANSION	$84,625
2021	2021	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	001	3	3/24/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $670,341

Issue Date FY: 2020 ( Subtotal = $555,054 )
2020	2020	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	000	3	7/24/2020	NON-COMPETING CONTINUATION	$555,054
														Subtotal = $555,054

Issue Date FY: 2019 ( Subtotal = $980,603 )
2019	2019	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	002	2	8/1/2019	SUPPLEMENT FOR EXPANSION	$425,550
2019	2019	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	001	2	6/28/2019	NON-COMPETING CONTINUATION	$555,053
2019	2018	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	000	1	3/6/2019	NEW	$0
														Subtotal = $980,603

Issue Date FY: 2018 ( Subtotal = $555,053 )
2018	2018	WOODS HOLE OCEANOGRAPHIC INSTITUTION	266 WOODS HOLE RD	WOODS HOLE	MA	02543	BARNSTABLE	USA	Environmental Health	000	1	9/18/2018	NEW	$555,053
														Subtotal = $555,053

Grand Total All Awards = $5,024,495

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Woods Hole Center for Oceans and Human Health

Award Number: P01ES028938

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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