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Predicting and Understanding the Use of Nicotine Products In a Rapidly Evolving Nicotine Marketplace: The International Nicotine Product, Policy, and Market (INPAM) Study

Award Number: P01CA200512
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/19/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Predicting and Understanding the Use of Nicotine Products In a Rapidly Evolving Nicotine Marketplace: The International Nicotine Product, Policy, and Market (INPAM) Study - OVERALL SUMMARY/ABSTRACT The proposed renewal of this P01 builds upon the longstanding International Tobacco Control (ITC) Policy Evaluation Project, which has used cross-country comparisons and a common mediation model to evaluate the behavioral impacts of national-level tobacco control policies. The current P01 has extensively researched and documented the transitions between cigarettes and nicotine vaping products and how policies impact their use. For the renewal period, we are adding heated tobacco products, thus extending our previous two-product model to three products, but otherwise maintaining a similar team structure and research approach. The goal of this P01 renewal application is to address the question “What have different countries done to regulate tobacco products and how has this impacted tobacco use behaviors?” Our common integrated theoretical framework enables us to examine how and why policies and industry actions exert effects, as well as explore under what conditions products or policy interventions might translate into actual population-level impacts. We focus on the well-established 4 `P's' – product, price, placement, and promotion, and how public health policy and industry actions impact consumer perceptions, behavior, and ultimately health endpoints. Comparing the experiences of different countries with varying regulatory approaches is intended to inform United States public policy, based upon the best science available to maximize population health. To accomplish this, we propose to analyze policies and industry actions in different jurisdictions to answer the following three integrated questions: 1) Does the policy/industry action have an impact? (causality); 2) Under what conditions is it effective? (moderation); and 3) How is it effective? (mediation). The proposed studies assess direct and indirect or unintended effects that can affect the overall impact of a policy or action. We propose to conduct this work with four inter-related Projects, an Administrative Core, and two Shared Resource Cores, which collectively will: 1) track cohorts of adult tobacco users in 7 countries; 2) conduct repeated cross sectional surveys of youth and young adults in 3 countries; 3) utilize the Experimental Tobacco Marketplace to evaluate the effects of product availability, policy actions, and the illicit marketplace; and 4) perform statistical modeling using input from the Projects to predict consumer response. The three P01 specific aims are to: 1) understand how policies and industry actions impact consumer behavior; 2) develop scientific methods for assessing response to policies; and 3) forecast population impact of different policy approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,276,812 )
2024	2024	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	001	9	9/6/2024	NON-COMPETING CONTINUATION	$1,276,812
2024	2023	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	8	3/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,276,812

Issue Date FY: 2023 ( Subtotal = $1,965,406 )
2023	2023	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	8	9/1/2023	NON-COMPETING CONTINUATION	$1,965,406
														Subtotal = $1,965,406

Issue Date FY: 2022 ( Subtotal = $2,157,518 )
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	003	7	8/30/2022	NON-COMPETING CONTINUATION	$2,051,983
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	004	7	9/6/2022	SUPPLEMENT FOR EXPANSION	$105,535
2022	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	002	6	2/10/2022	COMPETING CONTINUATION	$187,655
2022	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	6	11/10/2021	COMPETING CONTINUATION	$0
2022	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	001	5	2/10/2022	NON-COMPETING CONTINUATION	-$187,655
														Subtotal = $2,157,518

Issue Date FY: 2021 ( Subtotal = $2,112,413 )
2021	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	001	6	9/23/2021	COMPETING CONTINUATION	$2,112,413
2021	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	5	9/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,112,413

Issue Date FY: 2020 ( Subtotal = $2,556,067 )
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	5	3/20/2020	NON-COMPETING CONTINUATION	$2,556,067
														Subtotal = $2,556,067

Issue Date FY: 2019 ( Subtotal = $3,289,159 )
2019	2019	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	4	3/28/2019	NON-COMPETING CONTINUATION	$3,289,159
														Subtotal = $3,289,159

Issue Date FY: 2018 ( Subtotal = $3,709,874 )
2018	2018	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	002	3	5/23/2018	NON-COMPETING CONTINUATION	$289,340
2018	2018	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	3	5/17/2018	SUPPLEMENT FOR EXPANSION	$816,472
2018	2018	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	3	3/23/2018	NON-COMPETING CONTINUATION	$2,604,062
														Subtotal = $3,709,874

Issue Date FY: 2017 ( Subtotal = $3,033,680 )
2017	2017	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	001	2	6/7/2017	NON-COMPETING CONTINUATION	$303,368
2017	2017	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	2	3/20/2017	NON-COMPETING CONTINUATION	$2,730,312
														Subtotal = $3,033,680

Issue Date FY: 2016 ( Subtotal = $3,306,202 )
2016	2016	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Cause and Prevention Research	001	1	5/17/2016	NEW	$344,199
2016	2016	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Cause and Prevention Research	000	1	4/19/2016	NEW	$2,962,003
														Subtotal = $3,306,202

Grand Total All Awards = $23,407,131

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Predicting and Understanding the Use of Nicotine Products In a Rapidly Evolving Nicotine Marketplace: The International Nicotine Product, Policy, and Market (INPAM) Study

Award Number: P01CA200512

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/19/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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