Sunday, September 14, 2025 9/14/2025

NORMAL & NEOPLASTIC GROWTH IN THE BRAIN

Award Number: P01CA096832
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2003
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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NORMAL & NEOPLASTIC GROWTH IN THE BRAIN - Overall Program Summary Brain tumors are the most common pediatric solid malignancies, and the leading cause of cancer-related death in children. The long-term goal of this Program Project is to improve understanding and treatment of diffuse intrinsic pontine glioma (DIPG) and medulloblastoma (MB), which cause devastating mortality and morbidity in children. Over the last funding period, P01 investigators Baker, Roussel and Gilbertson demonstrated important contributions of epigenetic dysregulation in DIPG and MB, a role for pediatric brain tumor mutations in stress response, and therapeutic vulnerabilities in MB subtypes. P01 Investigator Northcott joins as a new Project leader with a proposal based on the discovery of a new MB cancer predisposition gene. This highly interactive team proposes an integrated series of experiments to leverage recent progress and the most advanced techniques to investigate aberrant cell fate/cell state regulation, to determine the contribution of epigenome, transcriptome and proteome dysregulation to disrupted development and tumorigenesis, and to identify developmental and epigenetic functional dependencies and test therapeutic vulnerabilities of pediatric hindbrain tumors. In Project 1, S Baker is focused on the contribution of H3K27M mutations in disrupted development, tumor initiation and spatiotemporal selectivity of tumorigenesis, and how cooperative contributions of ACVR1 and PI3K/mTOR pathways influence heterogeneity of therapeutic response to selective inhibitors. In Project 2, M Roussel investigates the role of the methyltransferase SMYD3, and tests drug combinations that enhance efficacy of methyltransferase inhibitors in the Group 3 MB subtype. In Project 3, P Northcott evaluates how loss of function in ELP1 drives MB predisposition, perturbs regulation of translation elongation, and cooperates with other mutations in the SHH-MB subtype. In Project 4, R Gilbertson investigates how DDX3X mutations disrupt cell fate decisions, transcription and translation regulation, and investigates novel therapies to exploit the defective blood-brain-barrier in WNT-MB. All four projects rely on the outstanding expertise in Core B, where all next-generation sequence data will be analyzed including integrated cross-comparison of data from multiple projects, and rigorous biostatistical approaches will be applied for experimental design and interpretation. Core C is integral to all projects and will provide expert neuropathological review of all tumor models studied in the program to assess their similarity and relevance to primary human disease and will assist with phenotype analyses and optimizing immunohistochemical analyses. The collective efforts of the Program will impact our understanding of disease pathogenesis of DIPG and MB, extend beyond pediatric hindbrain tumors, to enhance understanding of how aberrant regulation of the epigenome, transcriptome and proteome disrupt normal development and contribute to cancer. Our success is guaranteed by our strong track record of productive collaborations, the unique resources and the outstanding Cores to facilitate the acquisition, exchange, and integration of data.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,864,889 )
2025	2025	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	20	8/20/2025	NON-COMPETING CONTINUATION	$1,864,889
														Subtotal = $1,864,889

Issue Date FY: 2024 ( Subtotal = $1,771,644 )
2024	2024	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	19	8/27/2024	NON-COMPETING CONTINUATION	$1,771,644
														Subtotal = $1,771,644

Issue Date FY: 2023 ( Subtotal = $1,864,889 )
2023	2023	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	18	9/8/2023	NON-COMPETING CONTINUATION	$1,827,591
2023	2023	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	001	18	9/22/2023	NON-COMPETING CONTINUATION	$37,298
														Subtotal = $1,864,889

Issue Date FY: 2022 ( Subtotal = $1,827,591 )
2022	2022	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	17	8/24/2022	NON-COMPETING CONTINUATION	$1,827,591
														Subtotal = $1,827,591

Issue Date FY: 2021 ( Subtotal = $1,884,764 )
2021	2021	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	16	9/1/2021	COMPETING CONTINUATION	$1,884,764
2021	2019	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	001	15	9/3/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,884,764

Issue Date FY: 2020 ( Subtotal = $590,439 )
2020	2020	ST. JUDE CHILDREN'S RESEARCH HOSPITAL	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	15	8/19/2020	SUPPLEMENT FOR EXPANSION	$590,439
														Subtotal = $590,439

Issue Date FY: 2019 ( Subtotal = $1,899,162 )
2019	2019	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	15	5/16/2019	NON-COMPETING CONTINUATION	$1,899,162
														Subtotal = $1,899,162

Issue Date FY: 2018 ( Subtotal = $1,999,508 )
2018	2018	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	14	5/11/2018	NON-COMPETING CONTINUATION	$1,999,508
														Subtotal = $1,999,508

Issue Date FY: 2017 ( Subtotal = $2,039,886 )
2017	2017	ST. JUDE CHILDREN'S RESEARCH HOSPITAL	262 DANNY THOMAS PL MAILSTOP # 509	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	13	5/26/2017	NON-COMPETING CONTINUATION	$2,039,886
														Subtotal = $2,039,886

Issue Date FY: 2016 ( Subtotal = $2,072,072 )
2016	2016	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	12	5/20/2016	NON-COMPETING CONTINUATION	$2,072,072
														Subtotal = $2,072,072

Issue Date FY: 2015 ( Subtotal = $2,082,888 )
2015	2015	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	11	6/19/2015	COMPETING CONTINUATION	$2,056,188
2015	2015	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	001	11	6/25/2015	COMPETING CONTINUATION	$26,700
														Subtotal = $2,082,888

Issue Date FY: 2013 ( Subtotal = $1,723,420 )
2013	2013	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	001	10	3/20/2013	NON-COMPETING CONTINUATION	$869,565
2013	2013	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	002	10	7/2/2013	NON-COMPETING CONTINUATION	$928,715
2013	2012	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	9	3/18/2013	SUPPLEMENT FOR EXPANSION	-$74,860
														Subtotal = $1,723,420

Issue Date FY: 2012 ( Subtotal = $2,030,367 )
2012	2012	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	001	9	4/13/2012	SUPPLEMENT FOR EXPANSION	$98,000
2012	2012	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	9	4/13/2012	NON-COMPETING CONTINUATION	$1,932,367
														Subtotal = $2,030,367

Issue Date FY: 2011 ( Subtotal = $2,022,849 )
2011	2011	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	002	8	6/21/2011	SUPPLEMENT FOR EXPANSION	$90,492
2011	2011	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	001	8	5/20/2011	NON-COMPETING CONTINUATION	$85,659
2011	2011	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	8	3/16/2011	NON-COMPETING CONTINUATION	$1,846,698
														Subtotal = $2,022,849

Issue Date FY: 2010 ( Subtotal = $1,992,126 )
2010	2010	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	7	4/1/2010	NON-COMPETING CONTINUATION	$1,992,126
														Subtotal = $1,992,126

Issue Date FY: 2009 ( Subtotal = $1,953,065 )
2009	2009	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Cause and Prevention Research	000	6	4/1/2009	COMPETING CONTINUATION	$1,953,065
														Subtotal = $1,953,065

Issue Date FY: 2007 ( Subtotal = $1,770,072 )
2007	2007	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	000	5	3/29/2007	NON-COMPETING CONTINUATION	$1,770,072
														Subtotal = $1,770,072

Issue Date FY: 2006 ( Subtotal = $1,772,819 )
2006	2006	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	000	4	4/14/2006	NON-COMPETING CONTINUATION	$1,772,819
														Subtotal = $1,772,819

Issue Date FY: 2005 ( Subtotal = $1,765,653 )
2005	2005	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	000	3	5/9/2005	NON-COMPETING CONTINUATION	$1,765,653
														Subtotal = $1,765,653

Issue Date FY: 2004 ( Subtotal = $1,717,159 )
2004	2004	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	001	2	3/18/2004	SUPPLEMENT FOR EXPANSION	$330,950
2004	2004	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Biology Research	000	2	3/15/2004	NON-COMPETING CONTINUATION	$1,386,209
														Subtotal = $1,717,159

Issue Date FY: 2003 ( Subtotal = $1,354,332 ) (Continued on the next page)
Grand Total All Awards = $37,999,594

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NORMAL & NEOPLASTIC GROWTH IN THE BRAIN

Award Number: P01CA096832

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2003

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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