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HEMATOPOIETIC CELL TRANSPLANTATION FOR HEMATOLOGIC MALIGNANCIES

Award Number: P01CA030206
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/1997
PERIOD OF PERFORMANCE END DATE: 03/31/2013

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HEMATOPOIETIC CELL TRANSPLANTATION FOR HEMATOLOGIC MALIGNANCIES - DESCRIPTION (provided by applicant): This Program Project Grant application seeks support for translational clinical research studies to address some of the major obstacles to successful autologous and allogeneic hematopoietic cell transplantation (HCT) for hematologic malignancies. Thus, the overall goals of this grant are to: 1. To improve the long-term, disease-free survival of patients with hematological malignancy, 2. To extend the potential benefits of HCT to older patients with leukemia and lymphoma by the development of more effective and safer transplant regimens, 3. To translate previous laboratory observations in virology and tumor immunology made during the previous funding period into effective treatment strategies for patients undergoing HCT, and 4. To systematically delineate the short-term and long-term neurocognitive problems that afflict HCT recipients. This grant consists of four translational clinical projects and three cores. Project I entitled "Radioimmunotherapy-based Transplant Regimens for Treatment of B-cell Lymphoma and Acute Myelogenous Leukemia" is focused on developing novel RIT-based preparative regimens in both the autologous and allogeneic with improved anti-tumor potency and tolerability and which can be tested in older patients with these diseases. Project II entitled "Targeting Post-Transplant Minimal Residual CD19+ ALL with Genetically Modified CD19-specific T-cells," will pilot adoptive therapy utilizing CD19-specific genetically-modified T cells as a strategy to target post-HCT minimal residual disease. In this project we also answer important questions about the immunobiology (in vivo expansion, homing and targeting to sites of disease) of donor-derived T-cell adoptive transfer in recipients of allogeneic T-cell depleted HCT for CD19+ ALL. Project III entitled "Vaccine Induced Immunity to CMV", will test the first CMV vaccine intended for PBSC donors for augmenting transfer of CMV immunity to the patient with the goal of limiting post-HCT viremia. The investigators in this grant will be supported by three cores. The Administrative/Regulatory Affairs Core will oversee all administrative, financial, scientific review and data sharing for investigators in the grant and because seven of the trials will be conducted under institutionally-sponsored FDA INDs, Core A will also oversee the timely completion and submission of documents related to these INDs. Core B will continue to do data collection and management, and statistical analysis, and provide input into the design and publication of studies resulting from work in this grant. Core C will continue to provide long term follow-up and analysis of the recovery and health problems encountered by HCT-recipients treated on studies in this grant. In summary, the Program Project Grant renewal represents the ongoing, highly translational evolution of research by an integrated group of investigators focused on improving the outcome of HCT for patients with hematologic malignancies, and in particular, the first clinical applications of novel therapeutic interventions derived from laboratories in our program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2010	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	28	9/20/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $3,355,009 )
2010	2010	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	004	28	7/14/2010	SUPPLEMENT FOR EXPANSION	$91,675
2010	2010	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	006	28	7/16/2010	SUPPLEMENT FOR EXPANSION	$101,770
2010	2010	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	003	28	7/13/2010	NON-COMPETING CONTINUATION	$3,041,125
2010	2010	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	005	28	7/15/2010	SUPPLEMENT FOR EXPANSION	$31,635
2010	2010	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	001	27	2/19/2010	SUPPLEMENT FOR EXPANSION	$88,804
2010	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	27	10/20/2009	SUPPLEMENT FOR EXPANSION	$0
2010	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	002	27	7/8/2010	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,355,009

Issue Date FY: 2009 ( Subtotal = $3,115,197 )
2009	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	27	5/13/2009	NON-COMPETING CONTINUATION	$2,987,761
2009	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	002	27	10/16/2009	SUPPLEMENT FOR EXPANSION	$0
2009	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	004	27	9/30/2009	SUPPLEMENT FOR EXPANSION	$0
2009	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	001	27	7/10/2009	SUPPLEMENT FOR EXPANSION	$76,071
2009	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	003	27	9/24/2009	SUPPLEMENT FOR EXPANSION	$51,365
														Subtotal = $3,115,197

Issue Date FY: 2008 ( Subtotal = $2,995,161 )
2008	2008	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	001	26	5/19/2008	SUPPLEMENT FOR EXPANSION	$86,513
2008	2008	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	26	5/14/2008	NON-COMPETING CONTINUATION	$2,908,648
														Subtotal = $2,995,161

Issue Date FY: 2007 ( Subtotal = $2,866,163 )
2007	2007	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	25	4/18/2007	NON-COMPETING CONTINUATION	$2,776,839
2007	2007	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	001	25	6/21/2007	SUPPLEMENT FOR EXPANSION	$89,324
														Subtotal = $2,866,163

Issue Date FY: 2006 ( Subtotal = $2,960,503 )
2006	2006	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	24	3/29/2006	COMPETING CONTINUATION	$2,960,503
														Subtotal = $2,960,503

Issue Date FY: 2005 ( Subtotal = $359,000 )
2005	2005	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	001	23	5/19/2005	SUPPLEMENT FOR EXPANSION	$359,000
														Subtotal = $359,000

Issue Date FY: 2004 ( Subtotal = $3,090,843 )
2004	2004	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	23	5/20/2004	NON-COMPETING CONTINUATION	$3,090,843
														Subtotal = $3,090,843

Issue Date FY: 2003 ( Subtotal = $3,198,005 )
2003	2003	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	22		OTHER REVISION	$3,098,004
2003	2003	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	001	22	8/19/2003	SUPPLEMENT FOR EXPANSION	$100,001
														Subtotal = $3,198,005

Issue Date FY: 2002 ( Subtotal = $3,352,821 )
2002	2002	CITY OF HOPE NATIONAL MEDICAL CENTER	1500 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	21	4/24/2002	NON-COMPETING CONTINUATION	$3,352,821
														Subtotal = $3,352,821

Issue Date FY: 2001 ( Subtotal = $3,156,028 )
2001	2001	CITY OF HOPE NATIONAL MEDICAL CENTER	1500 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	20	8/27/2001	NON-COMPETING CONTINUATION	$3,156,028
														Subtotal = $3,156,028

Issue Date FY: 2000 ( Subtotal = $3,395,804 )
2000	2000	CITY OF HOPE NATIONAL MEDICAL CENTER	1500 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	19	7/24/2000	COMPETING CONTINUATION	$3,395,804
														Subtotal = $3,395,804

Issue Date FY: 1999 ( Subtotal = $2,351,700 )
1999	1999	CITY OF HOPE NATIONAL MEDICAL CENTER	1500 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	18	8/26/1999	NON-COMPETING CONTINUATION	$2,351,700
														Subtotal = $2,351,700

Issue Date FY: 1998 ( Subtotal = $2,211,851 )
1998	1998	CITY OF HOPE NATIONAL MEDICAL CENTER	1500 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Treatment Research	000	17	9/18/1998	NON-COMPETING CONTINUATION	$2,211,851
														Subtotal = $2,211,851

Grand Total All Awards = $36,408,085

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HEMATOPOIETIC CELL TRANSPLANTATION FOR HEMATOLOGIC MALIGNANCIES

Award Number: P01CA030206

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/1997

PERIOD OF PERFORMANCE END DATE: 03/31/2013

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