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Tissue Regulation of T Cell Function

Award Number: P01AI102851
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2014
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Tissue Regulation of T Cell Function - PROJECT SUMMARY / ABSTRACT Successful immunity relies on the rapid orchestration of diverse immune cell types that work in a dynamic and cooperative manner to drive location-dependent effector function. Immune cells do not work in isolation, and cooperation between immune cell types requires the sensing of local position-dependent cues that enable immune cells to aggregate into niches to exchange signals in a series of complex feedback loops. These coordinated interactions are critical throughout the developing immune response, from early activation events in inflamed lymph nodes through to effector function and resident memory in inflamed/infected targeted non- lymphoid tissues. A comprehensive understanding of immune responses thus requires the ability to examine the dynamic spatial and temporal exchange of information, in situ, in changing locations within and between tissues. To gain new insight into the biological complexity of immune activation in tissues, this P01 renewal brings immunologists and engineers together into the Programs multi-disciplinary scientific team, adding new concepts, perspectives, and tools to enable immunological questions to be addressed at ever higher spatial and temporal resolution. We aim to integrate dynamic intravital multiphoton microscopy with spatially defined transcriptomics to address fundamental questions about how topographical organization shapes T cell priming and effector function in response to infection. Shared models of infection examined in the lymph nodes and respective skin and lung tissue will enable integration of information across immune response time and space. The goal of this Program Project is to establish new paradigms in tissue immunity by gaining insight into cooperative events that shape immune cell positioning for exchange of signals that regulate effector function in lymphoid and non-lymphoid tissues. By spatially resolving immune response dynamics and transcriptional programs together, we aim to uncover new actionable strategies, based on the principles of immune position/zonation, to overcome poorly immunogenic environments and diminish overt inflammation. Project 1. Spatial Control of Effector T cell Activation. Dr. Deborah Fowell. Project 2. IL-17 Regulates Spatiotemporal Niches in LN. Dr. Mandy McGeachy. Project 3. Spatiotemporal Regulation of T cell Priming. Dr. Brian Rudd. Project 4. Monocytes Support Durable Tissue-Resident T cell Immunity. Dr. Minsoo Kim. Core A. Administrative. Dr. Fowell, Director. Core B. Imaging. Dr. Chris Xu, Director. Drs. Nishimura and Schaffer Co-directors. Core C. Spatial Transcriptomics. Dr. Iwijn De Vlaminck, Director.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,676,293 )
2026	2026	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Allergy and Infectious Diseases Research	001	11	6/1/2026	COMPETING CONTINUATION	$2,676,294
2026	2023	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Allergy and Infectious Diseases Research	000	10	1/20/2026	NON-COMPETING CONTINUATION	-$1
														Subtotal = $2,676,293

Issue Date FY: 2023 ( Subtotal = $2,416,175 )
2023	2023	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Allergy and Infectious Diseases Research	000	10	8/16/2023	NON-COMPETING CONTINUATION	$2,416,175
														Subtotal = $2,416,175

Issue Date FY: 2022 ( Subtotal = $2,418,260 )
2022	2022	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Allergy and Infectious Diseases Research	000	9	8/23/2022	NON-COMPETING CONTINUATION	$2,418,260
														Subtotal = $2,418,260

Issue Date FY: 2021 ( Subtotal = $2,420,282 )
2021	2021	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Allergy and Infectious Diseases Research	001	8	8/30/2021	NON-COMPETING CONTINUATION	$2,420,282
2021	2020	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Allergy and Infectious Diseases Research	000	7	10/22/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,420,282

Issue Date FY: 2020 ( Subtotal = $2,422,229 )
2020	2020	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Allergy and Infectious Diseases Research	002	7	8/18/2020	NON-COMPETING CONTINUATION	$2,422,229
2020	2019	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Allergy and Infectious Diseases Research	001	6	3/24/2020	COMPETING CONTINUATION	$122,642
2020	2018	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Allergy and Infectious Diseases Research	000	5	3/24/2020	NON-COMPETING CONTINUATION	-$122,642
														Subtotal = $2,422,229

Issue Date FY: 2019 ( Subtotal = $2,434,774 )
2019	2019	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Allergy and Infectious Diseases Research	001	6	8/26/2019	COMPETING CONTINUATION	$2,434,774
2019	2018	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Allergy and Infectious Diseases Research	000	5	8/23/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,434,774

Issue Date FY: 2018 ( Subtotal = $1,643,388 )
2018	2018	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Allergy and Infectious Diseases Research	000	5	5/22/2018	NON-COMPETING CONTINUATION	$1,643,388
														Subtotal = $1,643,388

Issue Date FY: 2017 ( Subtotal = $1,643,388 )
2017	2017	UNIVERSITY OF ROCHESTER	601 ELMWOOD AVE	ROCHESTER	NY	14642	MONROE	USA	Allergy and Infectious Diseases Research	000	4	5/26/2017	NON-COMPETING CONTINUATION	$1,643,388
														Subtotal = $1,643,388

Issue Date FY: 2016 ( Subtotal = $1,859,388 )
2016	2016	UNIVERSITY OF ROCHESTER	1325 MOUNT HOPE AVE, SUITE 260	ROCHESTER	NY	14642	MONROE	USA	Allergy and Infectious Diseases Research	002	3	8/4/2016	NON-COMPETING CONTINUATION	$216,000
2016	2016	UNIVERSITY OF ROCHESTER	910 GENESEE STREET SUITE 200	ROCHESTER	NY	146113847	MONROE	USA	Allergy and Infectious Diseases Research	001	3	6/17/2016	NON-COMPETING CONTINUATION	$0
2016	2016	UNIVERSITY OF ROCHESTER	1325 MOUNT HOPE AVE, SUITE 260	ROCHESTER	NY	14642	MONROE	USA	Allergy and Infectious Diseases Research	000	3	6/2/2016	NON-COMPETING CONTINUATION	$1,643,388
														Subtotal = $1,859,388

Issue Date FY: 2015 ( Subtotal = $1,643,007 )
2015	2015	UNIVERSITY OF ROCHESTER	1325 MOUNT HOPE AVE, SUITE 260	ROCHESTER	NY	14642	MONROE	USA	Allergy and Infectious Diseases Research	000	2	5/8/2015	NON-COMPETING CONTINUATION	$1,643,007
														Subtotal = $1,643,007

Issue Date FY: 2014 ( Subtotal = $1,714,537 )
2014	2014	UNIVERSITY OF ROCHESTER	1325 MOUNT HOPE AVE, SUITE 260	ROCHESTER	NY	14642	MONROE	USA	Allergy and Infectious Diseases Research	000	1	5/20/2014	NEW	$1,714,537
														Subtotal = $1,714,537

Grand Total All Awards = $23,291,721

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Tissue Regulation of T Cell Function

Award Number: P01AI102851

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2014

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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