Thursday, November 21, 2024 11/21/2024

Harvard-wide Program on Antibiotic Resistance

Award Number: P01AI083214
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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SUMMARY The goal of the Harvard-wide Program on Antibiotic Resistance is to apply innovative advanced technologies to developing new strategies for treating leading causes of multidrug resistant hospital-associated infection caused by staphylococci and enterococci. Although much attention has appropriately been focused on the recent emergence of pan-resistant gram negative bacteria, staphylococci and enterococci remain the leading causes of both morbidity and mortality associated with infection by multidrug resistant ESKAPE pathogens, highlighting the limitation of current therapeutic approaches. This multi-investigator project brings together experts from fields ranging from mathematics and systems biology to infectious disease clinicians, and creates an infrastructure for them to work collaboratively and synergistically, bringing new insights and capabilities to bear in solving the leading public health crisis of antibiotic resistant infection. Important discoveries and advances were made in the previous period of support by pressing the envelope with new technologies, including the most advanced high throughput mutational and comparative genomic analyses yet conducted on these microbes. In the proposed continuation period, these technologies will be combined with the latest advances in microfluidics and single cell time lapse imaging, to reveal new vulnerabilities of these bacteria for targeting by new compounds. The development and use of innovative screens that de-risk targets as well as unveil new opportunities, inform the design of new and more efficacious compounds for treating multidrug resistant staphylococcal and enterococcal infection. Filling critical knowledge gaps related to the various mechanisms by which microbes survive antibiotic challenge, including stochastic entry into alternate growth states and actively reducing drug concentration through efflux, make this program exceptionally comprehensive in its approach. Finally, this project actively shares its results with the community by establishing and promoting information exchange and networking with other academic and industry scientists, and by ensuring important antibiotic discovery knowledge is preserved and transmitted to the next generation of scientists. As a result of internal and external synergies, the impact of the Harvard-wide Program on Antibiotic Resistance is much greater than would otherwise be possible through individual research efforts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,271,745 )
2024	2024	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	003	16	4/24/2024	NON-COMPETING CONTINUATION	$227,172
2024	2024	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	16	1/22/2024	NON-COMPETING CONTINUATION	$2,044,573
2024	2022	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	14	11/25/2023	COMPETING CONTINUATION	$405,329
2024	2020	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	13	11/25/2023	NON-COMPETING CONTINUATION	-$405,329
														Subtotal = $2,271,745

Issue Date FY: 2023 ( Subtotal = $2,292,953 )
2023	2023	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	15	1/26/2023	NON-COMPETING CONTINUATION	$2,292,953
														Subtotal = $2,292,953

Issue Date FY: 2022 ( Subtotal = $2,362,774 )
2022	2022	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	14	2/14/2022	COMPETING CONTINUATION	$2,362,774
2022	2020	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	13	2/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,362,774

Issue Date FY: 2020 ( Subtotal = $2,024,695 )
2020	2020	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	13	8/25/2020	NON-COMPETING CONTINUATION	$2,024,695
														Subtotal = $2,024,695

Issue Date FY: 2019 ( Subtotal = $2,033,774 )
2019	2019	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	12	8/15/2019	NON-COMPETING CONTINUATION	$1,975,237
2019	2019	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	12	9/10/2019	SUPPLEMENT FOR EXPANSION	$58,537
														Subtotal = $2,033,774

Issue Date FY: 2018 ( Subtotal = $1,982,034 )
2018	2018	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	11	8/7/2018	NON-COMPETING CONTINUATION	$1,982,034
														Subtotal = $1,982,034

Issue Date FY: 2017 ( Subtotal = $1,980,896 )
2017	2017	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	005	10	8/14/2017	NON-COMPETING CONTINUATION	$1,980,896
2017	2016	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	004	9	3/16/2017	COMPETING CONTINUATION	$560,654
2017	2016	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	9	3/9/2017	COMPETING CONTINUATION	$0
2017	2016	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	003	9	3/13/2017	COMPETING CONTINUATION	-$560,654
2017	2016	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	9	3/6/2017	COMPETING CONTINUATION	$560,654
2017	2015	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	8	3/6/2017	NON-COMPETING CONTINUATION	-$560,654
														Subtotal = $1,980,896

Issue Date FY: 2016 ( Subtotal = $2,061,148 )
2016	2016	MASSACHUSETTS EYE & EAR INFIRMARY, OFF OF RES ADMIN	243 CHARLES STREET	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	9	7/29/2016	COMPETING CONTINUATION	$2,061,148
														Subtotal = $2,061,148

Issue Date FY: 2015 ( Subtotal = $2,158,199 )
2015	2015	MASSACHUSETTS EYE & EAR INFIRMARY, OFF OF RES ADMIN	243 CHARLES STREET	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	8	8/13/2015	NON-COMPETING CONTINUATION	$2,158,199
														Subtotal = $2,158,199

Issue Date FY: 2014 ( Subtotal = $2,158,199 )
2014	2014	MASSACHUSETTS EYE & EAR INFIRMARY, OFF OF RES ADMIN	243 CHARLES STREET	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	7	8/1/2014	NON-COMPETING CONTINUATION	$2,158,199
														Subtotal = $2,158,199

Issue Date FY: 2013 ( Subtotal = $2,028,707 )
2013	2013	MASSACHUSETTS EYE & EAR INFIRMARY, OFF OF RES ADMIN	243 CHARLES STREET	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	6	8/7/2013	NON-COMPETING CONTINUATION	$2,028,707
														Subtotal = $2,028,707

Issue Date FY: 2012 ( Subtotal = $2,310,720 )
2012	2012	MASSACHUSETTS EYE & EAR INFIRMARY, OFF OF RES ADMIN	243 CHARLES STREET	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	5	8/15/2012	NON-COMPETING CONTINUATION	$2,310,720
														Subtotal = $2,310,720

Issue Date FY: 2011 ( Subtotal = $963,805 )
2011	2011	MASSACHUSETTS EYE & EAR INFIRMARY, OFF OF RES ADMIN	243 CHARLES STREET	BOSTON	MA	02114	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	4	7/11/2011	COMPETING CONTINUATION	$2,166,794
2011	2009	MASSACHUSETTS EYE & EAR INFIRMARY, OFF OF RES ADMIN	243 CHARLES STREET	BOSTON	MA	02114	SUFFOLK	USA	Trans-NIH Recovery Act Research Support	000	2	1/6/2011	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1,202,989
														Subtotal = $963,805

Issue Date FY: 2010 ( Subtotal = $3,576,840 )
2010	2010	MASSACHUSETTS EYE & EAR INFIRMARY, OFF OF RES ADMIN	243 CHARLES STREET	BOSTON	MA	02114	SUFFOLK	USA	Trans-NIH Recovery Act Research Support	002	3	8/11/2010	NON-COMPETING CONTINUATION	$2,260,927
2010	2009	SCHEPENS EYE RESEARCH INSTITUTE	20 STANIFORD STREET	BOSTON	MA	02114	SUFFOLK	USA	Trans-NIH Recovery Act Research Support	001	1	7/5/2010	NEW	-$1,403,229
2010	2009	MASSACHUSETTS EYE & EAR INFIRMARY, OFF OF RES ADMIN	243 CHARLES STREET	BOSTON	MA	02114	SUFFOLK	USA	Trans-NIH Recovery Act Research Support	000	2	7/5/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,519,620
2010	2009	SCHEPENS EYE RESEARCH INSTITUTE	20 STANIFORD STREET	BOSTON	MA	02114	SUFFOLK	USA	Trans-NIH Recovery Act Research Support	003	1	9/30/2010	NEW	$199,522
														Subtotal = $3,576,840

Issue Date FY: 2009 ( Subtotal = $2,519,620 )
2009	2009	SCHEPENS EYE RESEARCH INSTITUTE	20 STANIFORD STREET	BOSTON	MA	02114	SUFFOLK	USA	Trans-NIH Recovery Act Research Support	000	1	8/28/2009	NEW	$2,519,620
														Subtotal = $2,519,620

Grand Total All Awards = $32,726,109

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Harvard-wide Program on Antibiotic Resistance

Award Number: P01AI083214

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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