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Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study

Award Number: P01AG026276
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study - Overall: Project Summary/Abstract “Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study” (ACS) will determine when during the lifespan molecular markers of Alzheimer disease (AD) appear in the brain of cognitively normal, largely middle-age individuals and also will characterize the course of preclinical AD. With maturation of the original ACS cohort, we now will identify the factors that mediate the transition from preclinical AD to symptomatic AD (the latter term in this application is used to encompass both mild cognitive impairment due to AD and AD dementia). This renewal application examines the hypothesis that disrupted neural integrity predicts the transition from preclinical to symptomatic AD and thus proposes four Cores (Administration, Clinical, Fluid Biomarker, and Data Management and Biostatistics) to support four Projects: Project 1 (JC Morris and T Benzinger, Co-Project Leaders), “Tau burden and spatial spread in preclinical Alzheimer disease”; Project 2 (AM Fagan, PL), “Plasma and cerebrospinal fluid (CSF) biomarkers that predict risk for symptomatic Alzheimer disease”; Project 3 (B Ances, PL), “Alzheimer disease progression, host gut microbiome, and enteric dysfunction”; and Project 4 (D Head, PL), “Mechanisms and moderators of the effects of physical activity in preclinical AD”. Although these Cores and Projects each address unique Specific Aims, they will generate a wealth of cross-sectional and longitudinal data from ACS participants to permit a cohesive and comprehensive examination of the overarching Aims of this renewal application. Hence, the ACS as a whole is far greater than the sum of its Cores and Projects.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,717,867 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	20	4/1/2025	NON-COMPETING CONTINUATION	$3,717,867
														Subtotal = $3,717,867

Issue Date FY: 2024 ( Subtotal = $4,139,640 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Aging Research	000	19	4/17/2024	NON-COMPETING CONTINUATION	$4,139,640
														Subtotal = $4,139,640

Issue Date FY: 2023 ( Subtotal = $4,136,684 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	18	5/18/2023	NON-COMPETING CONTINUATION	$4,136,684
														Subtotal = $4,136,684

Issue Date FY: 2022 ( Subtotal = $4,222,569 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	002	17	4/8/2022	NON-COMPETING CONTINUATION	$4,222,569
2022	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	001	16	11/18/2021	COMPETING CONTINUATION	$1,499,207
2022	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	15	11/18/2021	NON-COMPETING CONTINUATION	-$1,499,207
														Subtotal = $4,222,569

Issue Date FY: 2021 ( Subtotal = $4,212,953 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	16	6/24/2021	COMPETING CONTINUATION	$4,212,953
														Subtotal = $4,212,953

Issue Date FY: 2020 ( Subtotal = $2,068,818 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	15	5/15/2020	NON-COMPETING CONTINUATION	$2,068,818
														Subtotal = $2,068,818

Issue Date FY: 2019 ( Subtotal = $2,335,673 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	001	14	7/31/2019	SUPPLEMENT FOR EXPANSION	$283,073
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	14	6/24/2019	NON-COMPETING CONTINUATION	$2,052,600
2019	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	003	13	8/24/2019	NON-COMPETING CONTINUATION	$0
2019	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	002	12	8/23/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,335,673

Issue Date FY: 2018 ( Subtotal = $2,085,733 )
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	13	5/14/2018	NON-COMPETING CONTINUATION	$2,085,733
														Subtotal = $2,085,733

Issue Date FY: 2017 ( Subtotal = $2,067,511 )
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	002	12	6/21/2017	NON-COMPETING CONTINUATION	$2,067,511
2017	2016	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	004	11	8/8/2017	COMPETING CONTINUATION	$38
2017	2016	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	001	11	2/1/2017	COMPETING CONTINUATION	$725,557
2017	2015	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	10	2/1/2017	NON-COMPETING CONTINUATION	-$725,557
2017	2015	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	003	10	8/8/2017	NON-COMPETING CONTINUATION	-$38
														Subtotal = $2,067,511

Issue Date FY: 2016 ( Subtotal = $2,038,685 )
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	11	9/17/2016	COMPETING CONTINUATION	$2,038,685
2016	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	631121408	SAINT LOUIS CITY	USA	Aging Research	000	10	9/17/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,038,685

Issue Date FY: 2015 ( Subtotal = $2,287,585 )
2015	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	10	6/8/2015	NON-COMPETING CONTINUATION	$2,287,585
														Subtotal = $2,287,585

Issue Date FY: 2014 ( Subtotal = $2,350,116 )
2014	2014	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	9	6/14/2014	NON-COMPETING CONTINUATION	$2,350,116
														Subtotal = $2,350,116

Issue Date FY: 2013 ( Subtotal = $2,591,094 )
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	7	8/13/2013	SUPPLEMENT FOR EXPANSION	$247,334
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	8	9/10/2013	NON-COMPETING CONTINUATION	$2,343,760
														Subtotal = $2,591,094

Issue Date FY: 2012 ( Subtotal = $1,857,806 )
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	7	8/3/2012	NON-COMPETING CONTINUATION	$1,857,806
														Subtotal = $1,857,806

Issue Date FY: 2011 ( Subtotal = $2,091,199 )
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	002	6	9/21/2011	COMPETING CONTINUATION	$1,863,199
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	5	7/8/2011	SUPPLEMENT FOR EXPANSION	$228,000
2011	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	003	5	9/21/2011	NON-COMPETING CONTINUATION	$0
2011	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	5	7/7/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,091,199

Issue Date FY: 2009 ( Subtotal = $1,620,871 )
2009	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	5	6/16/2009	NON-COMPETING CONTINUATION	$1,620,871
														Subtotal = $1,620,871

Issue Date FY: 2008 ( Subtotal = $1,670,503 )
2008	2008	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	4	6/19/2008	NON-COMPETING CONTINUATION	$1,590,775
2008	2008	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	002	3	4/11/2008	SUPPLEMENT FOR EXPANSION	$79,728
														Subtotal = $1,670,503

Issue Date FY: 2007 ( Subtotal = $1,380,651 ) (Continued on the next page)
Grand Total All Awards = $49,127,496

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Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study

Award Number: P01AG026276

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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