Saturday, September 30, 2023 9/30/2023

Healthy Aging and Senile Dementia

Award Number: P01AG003991
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Overall Project Summary The over-arching goal of the Healthy Aging and Senile Dementia (HASD) study is to determine the factors that signal the imminent development of symptomatic Alzheimer disease (AD) in cognitively normal older adults. In pursuing this goal, HASD also will examine whether these predictive factors differ between African Americans and non-Hispanic whites, are influenced by sleep, or might be offset by genetic variants that protect against developing symptomatic AD. Finally, HASD will evaluate a novel method of assessing cognitive performance in naturalistic settings via a smartphone application. To accomplish these goals, HASD will assess and follow a richly phenotyped cohort that includes both cognitively normal older adults (~75%) and those with early-stage symptomatic AD (~25%). The longitudinal assessment protocol includes standard and novel clinical and cognitive measures, a six-day in-home sleep study, magnetic structural imaging studies of the brain, positron emission tomography studies of the brain to reveal the cerebral hallmarks of AD, amyloid-beta plaques and tau deposition, and examination of blood for genetic studies and of cerebrospinal fluid for levels of amyloid-beta and tau. Five Cores (Administration, Clinical, Biostatistics, Neuropathology [includes the Biofluids Laboratory], and Imaging) will support four Projects that carry out the scientific aims of HASD: Project 1: “Characterization of Molecular Biomarker Profiles of AD throughout its Pathobiological Continuum” Project 2: “Sleep and Orexin: Potential Markers of Progression from Preclinical to Mildly Symptomatic Alzheimer Disease” Project 3: “Dissecting the Genetic Architecture of Resilience” Project 4: “Smartphone-Based `Burst' Cognitive Assessments”


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $3,705,084 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	40	5/18/2023	NON-COMPETING CONTINUATION	$3,705,084


Issue Date FY: 2022 ( Subtotal = $3,650,202 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	001	39	5/17/2022	NON-COMPETING CONTINUATION	$0
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	39	5/16/2022	NON-COMPETING CONTINUATION	$3,649,897
2022	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	002	35	9/23/2022	NON-COMPETING CONTINUATION	$305


Issue Date FY: 2021 ( Subtotal = $3,595,946 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	38	4/22/2021	NON-COMPETING CONTINUATION	$3,595,946


Issue Date FY: 2020 ( Subtotal = $3,536,589 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	002	37	3/23/2020	NON-COMPETING CONTINUATION	$3,536,589
2020	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	001	36	1/31/2020	COMPETING CONTINUATION	$613,327
2020	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	35	1/31/2020	NON-COMPETING CONTINUATION	-$613,327


Issue Date FY: 2019 ( Subtotal = $3,662,191 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	36	4/12/2019	COMPETING CONTINUATION	$3,662,191


Issue Date FY: 2018 ( Subtotal = $2,880,306 )
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	35	4/27/2018	NON-COMPETING CONTINUATION	$2,880,306
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	001	35	6/22/2018	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2017 ( Subtotal = $2,886,316 )
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	001	34	6/23/2017	NON-COMPETING CONTINUATION	$288,632
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Aging Research	000	34	4/27/2017	NON-COMPETING CONTINUATION	$2,597,684


Issue Date FY: 2016 ( Subtotal = $2,860,323 )
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	33	5/19/2016	SUPPLEMENT FOR EXPANSION	$995,526
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	33	4/22/2016	NON-COMPETING CONTINUATION	$1,864,797


Issue Date FY: 2015 ( Subtotal = $1,808,854 )
2015	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	32	4/8/2015	NON-COMPETING CONTINUATION	$1,808,854


Issue Date FY: 2014 ( Subtotal = $1,869,280 )
2014	2014	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	31	8/4/2014	COMPETING CONTINUATION	$1,869,280
2014	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	30	7/31/2014	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2013 ( Subtotal = $1,691,795 )
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	30	12/18/2012	NON-COMPETING CONTINUATION	$1,611,232
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	30	5/28/2013	NON-COMPETING CONTINUATION	$80,563


Issue Date FY: 2012 ( Subtotal = $1,831,586 )
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	29	2/13/2012	NON-COMPETING CONTINUATION	$150,189
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	29	12/30/2011	NON-COMPETING CONTINUATION	$1,681,397


Issue Date FY: 2011 ( Subtotal = $1,415,847 )
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	28	6/3/2011	NON-COMPETING CONTINUATION	$90,098
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	28	1/27/2011	NON-COMPETING CONTINUATION	$1,325,749


Issue Date FY: 2010 ( Subtotal = $2,411,877 )
2010	2010	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	27	3/8/2010	NON-COMPETING CONTINUATION	$1,911,877
2010	2010	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	27	9/30/2010	NON-COMPETING CONTINUATION	$500,000


Issue Date FY: 2009 ( Subtotal = $2,259,932 )
2009	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	001	25	3/10/2009	SUPPLEMENT FOR EXPANSION	$250,000
2009	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	003	26	5/8/2009	COMPETING CONTINUATION	$1,866,312
2009	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	004	26	6/8/2009	COMPETING CONTINUATION	$0
2009	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Trans-NIH Recovery Act Research Support	005	26	9/9/2009	SUPPLEMENT FOR EXPANSION	$143,620
2009	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	002	25	5/8/2009	SUPPLEMENT FOR EXPANSION	$0
2009	2008	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	25	5/8/2009	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2008 ( Subtotal = $1,892,466 )
2008	2008	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Aging Research	000	25	2/14/2008	NON-COMPETING CONTINUATION	$1,892,466


Issue Date FY: 2007 ( Subtotal = $1,872,829 ) (Continued on the next page)
Grand Total All Awards = $59,940,348

Sum of Action Amount is $59,940,348;

Grand Total = $59,940,348

Page 1 of 2 (71 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Healthy Aging and Senile Dementia

Award Number: P01AG003991

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer