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Using electrical nerve stimulation to control atrial fibrillation

Award Number: OT2OD028190
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER
PERIOD OF PERFORMANCE START DATE: 07/01/2020
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Using electrical nerve stimulation to control atrial fibrillation - Study Plan: Using electrical nerve stimulation to control atrial fibrillation Aim 1 will test the hypothesis that subcutaneous (Aim 1A) and transcutaneous (Aim 1B) electrical nerve stimulation are effective in reducing the frequencies of paroxysmal atrial fibrillation (AF) and the ventricular rate in patients with severe symptomatic AF unresponsive to conventional therapies. Aim 2 will test the hypothesis that in healthy subjects, electroacupuncture or TENS at LI-4 and LI-11 can acutely activate or suppress skin sympathetic nerve activity (SKNA). We further hypothesize that chronic TENS will reduce sympathetic output in humans. If confirmed, repeated TENS may be used in the future clinical trials to control AF.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	000	2	6/30/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	001	2	5/8/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	000	2	5/8/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	000	2	1/27/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	002	2	5/3/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	003	2	7/31/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	001	2	5/3/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	001	2	6/30/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	000	2	6/29/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $937,332 )
2021	2021	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	004	2	5/5/2021	SUPPLEMENT FOR EXPANSION	$937,332
2021	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	000	2	11/3/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2021	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	002	2	3/11/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$333,846
2021	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Trans-NIH Research Support	003	2	5/5/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2021	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Trans-NIH Research Support	001	1	3/11/2021	NEW	-$333,846
														Subtotal = $937,332

Grand Total All Awards = $937,332

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Using electrical nerve stimulation to control atrial fibrillation

Award Number: OT2OD028190

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

PERIOD OF PERFORMANCE START DATE: 07/01/2020

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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