To provide collaborative mechanism to identify and address the most significant HIV needs of persons with HIV, allocate resources effectively and appropriately to the greatest HIV burdened communities - Abstract Many individuals in Alabama have been diagnosed with human immunodeficiency virus (HIV) are not receiving treatment. In addition, an estimate 64 percent of the people living with HIV in Alabama are unaware of their infection and so, are not receiving care. The purpose of this guidance is to implement a comprehensive, person-centered HIV prevention and surveillance program to prevent new HIV infections and improve the health of people with HIV. In addition, this guidance focuses on community engagement, health equity, and syndemic and whole-person approaches to HIV prevention. The priorities for this guidance are to increase knowledge of HIV status, reduce HIV transmission, prevent new HIV infection, improve linkage to care and viral suppression, and maintain elimination of perinatal transmission. The 2022 data shows that Jefferson and Mobile counties are identified as the counites with the highest HIV prevalence in the state. These findings indicate that there is a need for increased HIV education, testing, and linkage to care. Data is assessed using statistical software to determine prevalence incidence in the area. The data used from this analysis comes from the Enhanced HIV/AIDS Reporting System (eHARS) for HIV positive patients. Data will be used to monitor HIV activity and funding be aligned to better match the burden of HIV infections.