WEAVE-NW - The Northwest Portland Area Indian Health Board’s (NPAIHB’s) Northwest Tribal Epidemiology Center (NWTEC) is submitting this application in response to CDC-RFA-DP-24-0025, A Cultural Approach to Good Health and Wellness in Indian Country (GHWIC). NPAIHB seeks funding under Component 2. Strategies and methods address several areas of Healthy People 2030, including Social Determinants of Health and Public Health Infrastructure. Through this project we seek to build the public health infrastructure addressing heart disease and stroke, diabetes, obesity, oral health, and other modifiable health risk factors. Outcomes: The long-term outcomes of this project are to increase the presence and quality of culturally-responsive chronic disease prevention initiatives, including the consumption of health-promoting and traditional foods; increase rates and duration of breastfeeding; reduce the prevalence of commercial tobacco use; reduce the incidence of type 2 diabetes, hypertension, and hypercholesterolemia; and reduce the prevalence of early childhood caries. Strategies and Activities: We will provide direct funding to our member tribes to expand C1 strategies and activities. We will provide training, technical assistance, evaluation support, health communication development and continued support of multi-sectoral partnerships through the project. Training topics will include epidemiology and data use, health planning, policy development, commercial tobacco cessation, maternal child health initiatives, chronic disease prevention and management, and breastfeeding promotion. Using our Tribal Policy Guide, developed in partnership with Northwest tribes, we will provide training and technical assistance on practical steps to assess community readiness, develop, and implement tribal policy to address chronic disease. We will coordinate and provide leadership for our multi-sector partnerships, including the Northwest Tribal Food Sovereignty Coalition (NTFSC) and the Northwest Tribal Breastfeeding Coalition (NWIBC). We will also continue to expand the Diabetes ECHO, which is a knowledge-sharing network linking tribal providers with experts and specialists in a virtual clinic setting. These clinics provide training and consultation for primary care clinicians and healthcare extenders to build their capacity to provide care in tribal communities. We will partner with the Maternal and Child Health ECHO to provide didactic and/or case presentations addressing maternal or youth tobacco use, breastfeeding, early childhood oral health, and first sovereign foods, including promoting water as a beverage. Collaborations: This application is supported by a resolution, passed unanimously by our member tribes, expands collaborative relationships to enhance health equity built over the past 10 years of the GHWIC project. WEAVE-NW project will collaborate with Area tribes awarded Component 1 funding, and additional tribes provided awards under this program. We will collaborate with CDC chronic disease sections relevant to the tribal objectives and NWTEC strategies to coordinate evidenced-based and culturally appropriate strategies. We will collaborate internally with all NWTEC projects, including the youth focused We R Native and I-Lead projects that are leaders in their use of social media platforms for media messaging strategies. We will also collaborate with tribal-serving organization partners, as well as with our regional states and Indian Health Service. Evaluation: The purpose of this evaluation is to identify the strengths and areas for improvement in WEAVE-NW’s support of policy, system, and environment changes (PSEs) to promote Northwest tribes’ health. Target Audience: WEAVE-NW will serve the 43 federally-recognized AI/AN tribes in Idaho, Oregon, and Washington states.