Paul Coverdell National Acute Stroke Program - Purpose: The Michigan Stroke Program (MiSP) is proposing to reduce the burden of stroke in Michigan (MI) by targeting census tracts with high stroke prevalence while addressing inequalities in stroke risk, care, and outcomes, and overall cardiovascular health. This will be achieved by expanding data systems to monitor and plan interventions in high-risk areas, creating bi-directional flow of information across clinical and community service organizations, increasing use of social and support services among those who are at high risk or have had a stroke, and expanding and strengthening the sustainability of established local stroke coalitions. Evidence-based quality improvement (QI) initiatives and strategies will be implemented at the local and state levels to mitigate risk factors, advance equitable access to stroke care and social services, and improve outcomes. Since 2013, MI has experienced a troubling shift in stroke mortality, reversing a decline that had lasted over three decades. Currently, MI ranks 10th worst (70.0 per 100,000) in the country for adult stroke mortality (CDC Atlas, 2018-2021). The increase in stroke mortality can be attributed in part to the increase in prevalence of stroke risk factors in MI adults. Disparities in risk, incidence, care, and outcomes by race, gender, age, and location have persisted. Flint and Detroit bear a disproportionate stroke burden due to historical inequalities in employment and housing and will be the primary populations of focus for this cooperative agreement. MiSP will expand collaborations in these cities and others to implement equity-focused interventions aimed at reducing stroke prevalence and improving outcomes in high-risk areas throughout MI. Outcomes: MiSP will concentrate efforts on the short, intermediate, and long-term population‐level outcomes indicated in the logic model included in the CDC Project Description for those at highest risk of stroke events and stroke patients across Stroke Systems of Care (SSOC). To achieve outcome goals, MiSP will extend the work of the Detroit and Flint Stroke Coalitions to improve local SSOC and engage with the communities they serve to minimize stroke risk. By the end of the period of performance, MiSP will achieve the following: reduced risk for strokes and stroke prevalence within targeted high risk census tracts, increased use of social and support services among those at highest risk of stroke within targeted census tracts, expanded data systems that encompass social service and bi-directional data flow, strengthened partnerships across SSOC (notably in Detroit and Flint), and increased use of Community Health Workers in high-risk census tracts.