The Hawaii Overdose Data to Action in States (OD2A-S) project aims to continue the progress of the surveillance and prevention activities of the previous Hawaii OD2A project to address the ongoing issues of the drug overdose epidemic in Hawai’i by working collaboratively and strategically with key partners from various sectors to implement and evaluate evidence-based strategies to achieve measurable improvements in the prevention, management, and reduction of opioid use with a focus on priority populations. The project will expand and build on key interventions currently being conducted and efforts will be carried out at the state, regional, and local levels to reach multiple settings and communities to maximize health improvement throughout Hawai’i’s diverse populations. The project also aims to enhance surveillance efforts by improving infrastructure, morbidity surveillance, mortality surveillance, and data linkage. Hawai’i has also developed activities for four key prevention strategies: Clinician/Health System Engagement and Health/IT PDMP Enhancement, Public Safety Partnerships/Interventions, Harm Reduction, and Community-Based Linkage to Care. Some of the short-term outcomes of this project include more timely, detailed, comprehensive, and actionable surveillance data, increased data sharing and data availability, and increased collaboration, coordination, and communication among community partners. Some of the long-term outcomes of this project are decreases in illicit opioid and stimulant use, including co-use with other substances, and decreases in nonfatal and fatal drug overdoses, especially those disproportionately affected by the overdose epidemic and those previously underserved by overdose prevention programs and the healthcare system overall.