Strengthening Vaccine-Preventable Disease Prevention and Response - The Missouri Department of Health and Senior Services (DHSS) seeks funding under the "Strengthening Vaccine-Preventable Disease Prevention and Response" Notice of Funding Opportunity (NOFO) to enhance vaccine access, address vaccine misinformation, and build public confidence in immunizations across the state. This initiative aligns with the Centers for Disease Control and Prevention's (CDC) objectives by implementing evidence-based strategies to strengthen immunization infrastructure, promote vaccination in areas with low vaccination rates, and improve preparedness for outbreak response. By leveraging strategic partnerships, data-driven approaches, and community engagement, this project aims to achieve measurable outcomes, including increased vaccination rates, reduced barriers in vaccine access, and enhanced public health systems. The proposed initiative will expand vaccine provider networks, strengthen collaborations with trusted community messengers, and combat vaccine hesitancy and misinformation. Funded through the CDC cooperative agreement (25-0007), this five-year initiative targets critical areas such as immunization access, and demand. It also addresses gaps in vaccine access exacerbated by the COVID-19 pandemic. Key objectives include improving vaccination coverage through targeted interventions, enhancing the state’s immunization information systems (IIS), and building capacity for rapid responses to public health emergencies. Local data will guide efforts to identify and address gaps in vaccine coverage while focusing on underserved and high-risk populations. This initiative aligns with national public health priorities to promote access to life-saving vaccines and protect communities from vaccine-preventable diseases. The Missouri Department of Health and Senior Services is committed to strengthening vaccine confidence and addressing differences in health outcomes. Through collaboration, innovation, and evidence-based strategies, this project will empower Missouri to build a more resilient public health infrastructure and safeguard the health of all Missourians.