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Leveraging Ambulatory Technology to Assess Cognitive-Affective Processes in Suicidal Ideation Among High-Risk Adolescents

Award Number: K99MH142686
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/16/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Leveraging Ambulatory Technology to Assess Cognitive-Affective Processes in Suicidal Ideation Among High-Risk Adolescents - PROJECT SUMMARY/ABSTRACT Suicide is the second leading cause of death among adolescents, and its rates have doubled since 2000. The period immediately following discharge from inpatient care is especially perilous, with a marked increase in suicide risk observed during this time. However, our ability to accurately predict suicide and intervene during this critical period has been largely limited due to a failure to identify short-term risk factors for suicidal thoughts and behaviors. Two particularly relevant factors for adolescents may be interpretation bias and emotional reactivity, as adolescence is marked by exponential cognitive and emotional growth. While previous studies have examined the effects of interpretation bias and emotional reactivity on suicide risk, most have considered them only as distal predictors or correlates. This Pathway to Independence Award seeks to conduct digital technology-based ambulatory assessments of interpretation bias and emotional reactivity and examine their relation to suicidal ideation among adolescents after they discharge from inpatient level of care. During the K99 phase, Dr. Park will receive training to develop the necessary expertise for conducting independent research in the R00 phase. In the R00 phase, he will lead a full-scale ambulatory study. Specifically, adolescents (N=100) admitted to an inpatient or partial hospital program due to acute suicide risk will be recruited. For 28 days post- discharge, they will complete daily surveys on their emotions and suicidal thoughts, along with a behavioral task assessing interpretation bias. The specific aims of this K99/R00 application are: 1) to identify the effects of in-lab interpretation bias and ambulatory emotional reactivity on ambulatory suicidal ideation (K99 Aim 1); 2) to test the feasibility of an ambulatory interpretation bias task in adolescents (K99 Aim 2); 3) to confirm the temporal association between interpretation bias, emotional reactivity, and momentary fluctuations in suicidal ideation after adolescents are discharged from inpatient care (R00 Aim 3). To ensure a successful transition to independence, the K99 training phase will provide Dr. Park with comprehensive training in five key areas: 1) translational digital health research for high-risk adolescents, with a focus on ambulatory assessment methods; 2) assessment of momentary interpretation bias; 3) assessment of momentary emotional reactivity; 4) advanced data analytic skills for intensive longitudinal data; and 5) professional development, including grantsmanship. A team of leading scholars will provide expert mentorship to support Dr. Park’s training goals within the highly resourced environment of Harvard Medical School and Massachusetts General Hospital. The K99 training will serve as a foundation for the R00 phase, which will, in turn, provide pilot data for future R- series awards. The proposed training plan and mentorship team will ensure Dr. Park’s successful transition to independence as a faculty member at an R1 institution and support his long-term career goal of employing low- burden, scalable assessment methods to develop risk models that enhance the proximal prediction of suicide risk and inform intervention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $128,924 )
2026	2026	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	1	9/17/2026	NEW	$128,924
														Subtotal = $128,924

Grand Total All Awards = $128,924

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Leveraging Ambulatory Technology to Assess Cognitive-Affective Processes in Suicidal Ideation Among High-Risk Adolescents

Award Number: K99MH142686

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/16/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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