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Comprehensive computational analysis of genetic and regulatory differences between individuals with African and European ancestries across four brain regions

Award Number: K99MD016964
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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Project Summary / Abstract Health disparities have endured for centuries. The disparity in research for biological variations is even greater, where the explosion of genetic and environmental data has focused almost exclusively on those of European ancestry (EA). In neuroscience and genomics, individuals with recent African ancestry (AA) account for less than 5% of large-scale genomic studies but are 20% more likely to experience a major mental health crisis. To compound this issue further, studies have linked genetic differences between AA and EA for divergent responses to antipsychotics. As a result, large-scale studies for neuropsychiatric disorders have limited diagnostic accuracy for non-European ancestry individuals, hindering the development of effective equitable neurotherapeutics and potentially increasing health disparities. Despite the clear urgent need, there are no large-scale studies examining genetic or regulatory differences between AA and EA in the human brain. This proposal seeks to address this gap in research by comparing AA with well-studied EA individuals. The initial goal of this proposal is to identify genetic and regulatory difference between AA (n=784) and EA (n=678) in postmortem caudate nucleus (n=420), dentate gyrus (n=161), dorsolateral prefrontal cortex (n=434), and hippocampus (n=447), compiled from one of the largest postmortem brain collections of psychiatric disorders. This diverse large-scale postmortem brain tissue will allow us to test the hypotheses of genetic variations influence on brain region-specific transcriptional and epigenetic changes for ancestry across prenatal and postnatal life. This MOSAIC (Maximizing Opportunities for Scientific and Academic Independent Careers) Postdoctoral Career Transition Award to Promote Diversity will be supported by excellent career development resources at the Lieber Institute for Brain Development and Johns Hopkins University, and training from a mentoring team of globally recognized experts in the fields of human genetics and advanced statistical methods. It will provide a first of its kind examination of ancestry in neuroscience, which will advance our understanding of genetic variation in the human brain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	LIEBER INSTITUTE, INC.	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Minority Health and Health Disparities Research	000	2	11/29/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $97,134 )
2023	2023	LIEBER INSTITUTE, INC.	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Minority Health and Health Disparities Research	002	2	1/11/2023	NON-COMPETING CONTINUATION	$0
2023	2023	LIEBER INSTITUTE, INC.	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Minority Health and Health Disparities Research	000	2	11/8/2022	NON-COMPETING CONTINUATION	$87,422
2023	2023	LIEBER INSTITUTE, INC.	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Minority Health and Health Disparities Research	003	2	1/27/2023	NON-COMPETING CONTINUATION	$9,712
2023	2022	LIEBER INSTITUTE, INC.	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Minority Health and Health Disparities Research	001	1	1/11/2023	NEW	$0
														Subtotal = $97,134

Issue Date FY: 2022 ( Subtotal = $100,000 )
2022	2022	LIEBER INSTITUTE, INC.	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Minority Health and Health Disparities Research	000	1	11/27/2021	NEW	$100,000
														Subtotal = $100,000

Grand Total All Awards = $197,134

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Comprehensive computational analysis of genetic and regulatory differences between individuals with African and European ancestries across four brain regions

Award Number: K99MD016964

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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