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Metasurface Optical Guidewire for percutaneous coronary intervention (PCI)

Award Number: K99HL173631
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/20/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Metasurface Optical Guidewire for percutaneous coronary intervention (PCI) - PROJECT SUMMARY / ABSTRACT Coronary artery disease, aggravated by arterial calcification, poses a significant challenge to successful percutaneous coronary intervention (PCI). Coronary artery calcification (CAC) reduces vessel compliance and increases the complexities of stent deployment, stent expansion, balloon expansion, and results in uneven drug distribution. Specifically, reduced vessel compliance prohibits stent delivery and reduces the ability of deployed stents to expand, or causing “stent regret”, resulting in stent failure through either restenosis or stent thrombosis. Importantly, these complications are exasperated in highly stenotic CAC lesions – hence, endovascular devices and therapeutic techniques are needed with improved safety and efficacy to advance the clinical management of CAC. The objective of this proposal is to develop novel metasurface optical guidewires for therapeutic applications to treat previously untreatable highly stenotic CAC lesions. Our project addresses these challenges by hypothesizing that: 1) metasurfaces are specialized planar lens elements that can provide optimal energy delivery over a sub-millimeter profile; 2) with advances in fiber-coupled diode laser technologies, fiber-optic metasurfaces are an attractive platform for endovascular devices; 2) a flexible, small-diameter fiber-optic embedded guidewire with metasurfaces – termed 'metasurface optical guidewires' – can offer dual benefits of a rapid exchange monorail for PCI devices and provide light-based endovascular therapeutic capabilities including laser intravascular lithotripsy (L-IVL). The metasurface optical guidewires and associated innovative light-based endovascular therapies will be successfully developed and demonstrated by completing the following specific aims: Aim 1: Design, develop and manufacture metasurface optical guidewires for precise control of intravascular laser dosimetry; Aim 2: Develop a PCI workflow for use of an metasurface optical guidewire for laser intravascular lithotripsy (L-IVL); Aim 3: Develop a PCI workflow and study L-IVL’s efficacy in a preclinical model; Aim 4: Evaluate L-IVL treatment efficacy in a pre-clinical CAC animal model. Successful completion of these aims will lead to the development of the metasurface optical guidewire and other innovative devices and procedures that can significantly improve PCI outcomes in patients with calcified coronary arteries, reducing complications and enhancing patient care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $122,625 )
2025	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Cardiovascular Diseases Research	000	2	7/4/2025	NON-COMPETING CONTINUATION	$122,625
														Subtotal = $122,625

Issue Date FY: 2024 ( Subtotal = $134,151 )
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Cardiovascular Diseases Research	000	1	8/16/2024	NEW	$134,151
														Subtotal = $134,151

Grand Total All Awards = $256,776

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Metasurface Optical Guidewire for percutaneous coronary intervention (PCI)

Award Number: K99HL173631

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/20/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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