Monday, December 15, 2025 12/15/2025

Inflammation-mediated platelet hyperreactivity and thrombosis

Award Number: K99HL156058
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 03/05/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Inflammation-mediated platelet hyperreactivity and thrombosis - Project Summary/Abstract The Candidate is an assistant professor in pediatrics and a young physician-scientist dedicated to developing an academic career focused on investigating the intersection of inflammation and thrombosis through the study of the mechanisms by which inflammation promotes platelet hyperreactivity. With a strong background in inflammation, megakaryocyte, and platelet biology, the candidate looks to develop new expertise in autophagy and metabolism to determine their contribution to platelet hyperreactivity and thrombosis. The Career Development Plan described in the proposal outlines 2 years of mentored training, including technical skill training and career development activities, to promote the successful transition to independence and future funding. The Candidate’s Mentors and Co-Mentors have proven track-records of excellent translational research productivity and successful mentorship. The Research Plan: Inflammation contributes to the development of cardiovascular disease (CVD) and promotes platelet hyperreactivity and thrombosis in older humans (aging) and patients with rheumatoid arthritis (RA). The thrombotic events experienced by these groups are characterized by platelet-rich arterial clots denoting that platelet hyperreactivity is central for the elevated morbidity and mortality in these populations. The central hypothesis of this application is that chronic inflammation promotes platelet hyperreactivity and thrombosis through the reprogramming of key platelet metabolic pathways. The work proposed in this application is set to elucidate the mechanisms by which chronic inflammation promotes platelet hyperreactivity through dysregulation of critical metabolic regulators of platelet function such as autophagy (aim 1) and the pentose phosphate pathway (PPP, [aim 2]) in older humans and in patients with rheumatoid arthritis (aim3). For this purpose, I have integrated multidisciplinary mentoring and advisory teams of world-known experts in autophagy (Andrew Thorburn, Ph.D.), metabolomics (Angelo D’Alessandro Ph.D.), and platelet biology (Matthew Rondina, MD) to guide the successful completion of the proposed work. The mentoring, skills, and tools developed throughout the K99 phase of this award will lay down a solid foundation to establish my independent research program focused on the study of the platelet metabolic determinants for hyperreactivity and thrombosis. Finally, and most important, discoveries from our research have the potential to improve the care and outcomes not only for older individuals and patients with RA but also children with chronic inflammatory conditions such as Juvenile Idiopathic Arthritis (JIA) and sickle cell disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$96,205 )
2025	2024	BLOODWORKS	921 TERRY AVE	SEATTLE	WA	98104	KING	USA	Blood Diseases and Resources Research	000	4	3/26/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2024	BLOODWORKS	921 TERRY AVE	SEATTLE	WA	98104	KING	USA	Blood Diseases and Resources Research	001	4	7/2/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$96,205
														Subtotal = -$96,205

Issue Date FY: 2024 ( Subtotal = $210,724 )
2024	2024	BLOODWORKS	921 TERRY AVE	SEATTLE	WA	98104	KING	USA	Blood Diseases and Resources Research	003	4	7/19/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$202,576
2024	2024	BLOODWORKS	921 TERRY AVE	SEATTLE	WA	98104	KING	USA	Blood Diseases and Resources Research	001	4	6/29/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$210,724
2024	2023	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Blood Diseases and Resources Research	000	3	6/27/2024	NON-COMPETING CONTINUATION	$0
2024	2023	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Blood Diseases and Resources Research	002	3	7/19/2024	NON-COMPETING CONTINUATION	-$202,576
														Subtotal = $210,724

Issue Date FY: 2023 ( Subtotal = $210,724 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Blood Diseases and Resources Research	000	3	3/22/2023	NON-COMPETING CONTINUATION	$210,724
														Subtotal = $210,724

Issue Date FY: 2022 ( Subtotal = $215,427 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Blood Diseases and Resources Research	000	2	6/13/2022	NON-COMPETING CONTINUATION	$215,427
														Subtotal = $215,427

Issue Date FY: 2021 ( Subtotal = $215,427 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Blood Diseases and Resources Research	000	1	3/4/2021	NEW	$215,427
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Blood Diseases and Resources Research	001	1	7/16/2021	NEW	$0
														Subtotal = $215,427

Grand Total All Awards = $756,097

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Inflammation-mediated platelet hyperreactivity and thrombosis

Award Number: K99HL156058

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 03/05/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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