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Linking physiology, computation and circuitry in the primate visual cortex

Award Number: K99EY037839
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Linking physiology, computation and circuitry in the primate visual cortex - PROJECT SUMMARY The aim of this proposal is to determine the biological underpinnings of canonical computations in the brain. The focus will be on how these computations manifest in primate visual system, which is the classical system for identifying such transformations of information. Canonical computations are fundamental processing patterns that underlie a wide range of neural functions, impacting perception and cognition across hierarchical brain networks. However, there are large families of possible biological circuits that could implement these computations and, likewise, vastly different computations can be implemented with the same or very similar neural circuitry. What is needed to advance our understanding of these computations in the brain is a way to bridge the gap between physiology, computation and circuitry in a tractable, generalizable model living system. Marmoset early visual areas V1 and V2 are the perfect testbed to develop models of cortico-cortical computations and circuits, some of which will generalize to the rest of the visual system and to hierarchical transformations of information throughout the primate neocortex. An exhaustive dataset of simultaneous V1 and V2 neural responses with high density electrophysiology and calcium imaging will be collected in combination with perturbations using virally mediated opto- and chemo-genetic tools to test models of a canonical interareal circuit. In contrast to the mouse model, where these tools have largely been developed and implemented, the marmoset has prototypical primate neural circuits closely related to our own, but in a simpler and more accessible brain than that of larger primates. The training aims of this proposal support the development of the analysis and genetic tools that are required to understand the transformation of information between V1 and V2. These support an independent research phase, to dissect the circuits involved in interareal transformations and extend the analysis to additional stages of the visual hierarchy. The overall goal of the project is to understand the transformation of information between areas in the visual system ultimately to arrive at a canonical model for cortico-cortical computation and circuitry across the brain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $132,173 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	1	4/13/2026	NEW	$132,173
														Subtotal = $132,173

Grand Total All Awards = $132,173

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Linking physiology, computation and circuitry in the primate visual cortex

Award Number: K99EY037839

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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