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Endocrine-Disrupting Chemical (EDC) Mixtures in Relation to Metabolic Syndrome (MetS) and Metabolomic Mechanisms in a Prospective Cohort of Hispanic Women

Award Number: K99ES037024
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/10/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Endocrine-Disrupting Chemical (EDC) Mixtures in Relation to Metabolic Syndrome (MetS) and Metabolomic Mechanisms in a Prospective Cohort of Hispanic Women - I am an environmental epidemiologist with a main research focus on the “exposome” and its role in obesity-related outcomes and chronic disease. The training presented in this proposal will enable me to become an independent public health researcher in the field of environmental epidemiology, specializing in endocrine-disrupting chemical (EDC) mixtures and long-term cardiometabolic health in women. This project addresses the role of EDCs in the onset of metabolic syndrome (MetS), which is a cluster of conditions that can increase the risk for heart disease and type 2 diabetes, as well as examines potential underlying mechanisms. This opportunity will allow me to hone the skills needed to become an independent investigator by 1) expanding my knowledge in exposure-mixture methods, 2) acquiring the tools to analyze and interpret high-dimensional metabolomics data, and 3) advancing my expertise in a relatively highly prevalent, yet understudied, metabolic condition. The rising MetS epidemic has reached alarming rates in North America, with a prevalence in adults of more than one-third in the US. Our research can directly benefit U.S. women by elucidating for the first time in humans the progression of EDC-mechanisms of action in MetS onset leveraging repeated metabolomics throughout postpartum and beyond. Currently, the etiology of MetS and its mechanisms of action are poorly understood. An emerging risk factor for MetS is exposure to environmental “obesogens” and EDCs. Endocrine disruptors can act in the body by mimicking steroid hormones and increasing oxidative stress, thereby triggering MetS components such as hypertension, abdominal adiposity, hyperglycemia, or dyslipidemia. Moreover, pregnancy is likely a susceptible period that could exacerbate the deleterious effects of EDCs with long-lasting consequences for women’s health. I will leverage ~400 pregnant Mexican women from the PROGRESS prospective cohort which has a wide array of different classes of EDCs, repeated mediators (metabolomics), and repeated MetS components to examine 1) the longitudinal association between EDC exposure-mixtures—phthalates, metals, air pollutants, pesticides, and PFAS—and MetS onset, 2) the subsequent alteration in individual metabolites and pathways stemming from these exposures at different time-points, and 3) the mediating longitudinal metabolomic features characteristic of MetS in women. This cohort in Mexico is uniquely valuable given the already existing and well-characterized data with unique components that are not available in any current U.S. cohort, including wide range of EDCs, and repeated metabolomics and MetS components. Its high prevalence of metabolic risk factors and wide range of environmental exposures enhance statistical power, maximizing rigor and cost-efficiency to evaluate exposure mixtures and metabolomics. These unparalleled characteristics from PROGRESS will enable us to draw more robust conclusions while conducting this research. The training originating from the K99 phase will ensure the correct implementation of chemical mixtures-MetS association analyses in the K99 and of mixture-omics and mediation analyses in the R00 phase.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $126,809 )
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	000	2	8/10/2026	NON-COMPETING CONTINUATION	$126,809
														Subtotal = $126,809

Issue Date FY: 2025 ( Subtotal = $126,970 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	000	1	9/9/2025	NEW	$126,970
														Subtotal = $126,970

Grand Total All Awards = $253,779

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Endocrine-Disrupting Chemical (EDC) Mixtures in Relation to Metabolic Syndrome (MetS) and Metabolomic Mechanisms in a Prospective Cohort of Hispanic Women

Award Number: K99ES037024

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/10/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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