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Metabolomic predictors of weight gain during pregnancy and the postpartum period in South African women living with HIV

Award Number: K43TW012887
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 09/01/2025

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Metabolomic predictors of weight gain during pregnancy and the postpartum period in South African women living with HIV - PROJECT SUMMARY People living with HIV (PLHIV) have a persistently reduced lifespan compared to their negative counterparts due to increased risk of metabolic co-morbidities such as diabetes and cardiovascular diseases. Among women of reproductive potential, gestational weight gain (GWG) and postpartum weight retention (PPWR) are known contributors to the onset of these metabolic co-morbidities. Early detection of pregnant women at risk of excessive GWG and PPWR can enable early interventions that will help minimize the occurrence of these co- morbidities in women living with HIV (WLHIV). The overarching goal of this proposal is to identify urine metabolites that are predictive of excessive GWG and PPWR in WLHIV. Candidate: Dr. Madlala is a Physiologist/Epidemiologist with training in molecular sciences, quantitative research methods and experience in field research implementation in South Africa. She is applying for a five-year Fogarty Emerging Global Leader Award to obtain the additional training, mentorship and experience required to become a leading independent investigator capable of obtaining R-series funding. Mentoring: She has assembled an exceptional multidisciplinary team with extensive expertise in metabolic outcomes of HIV research in sub- Saharan Africa. Drs. Myer (University of Cape Town, (UCT)) and Jao (Northwestern University) will serve as primary mentors providing complementary expertise on metabolic outcomes of WLHIV and clinical use of biomarkers. Dr. Goedecke (UCT, SAMRC), co-mentor, is a Physiologist with expertise in mechanistic science research. Dr. Kurland (Albert Einstein: expertise in metabolomics laboratory technique) and Dr. Balmert (Northwestern University: expertise in ‘omics’ data handling and pathway analysis) will serve as scientific advisors in these areas. Training: Specific training in biomarker discovery study design, ‘big’ data statistical analysis and metabolic pathway elucidation – will be achieved through intensive mentored training and formal coursework. This, combined with the experience gained through implementing her research aims, will establish Dr. Madlala’s independent research career investigating early biomarkers of adverse metabolic health in PLHIV. Research: The specific aims of this research are to: 1) assess whether HIV infection is associated with differences in urine metabolite species during the first trimester of pregnancy, 2) develop risk prediction models for (i) GWG, (ii) PPWR and (iii) postpartum adiposity using metabolites and clinical variables, and 3) elucidate the metabolic pathways of (i) GWG, (ii) PPWR and (iii) adiposity by applying pathway/network analysis to the prognostic metabolites identified. The results of this study will inform the development of urinary metabolite- based screening tool for adverse weight outcomes aimed at minimizing metabolic co-morbidities in pregnant and postpartum WLHIV. They will provide preliminary data needed to apply for an R01 to conduct a large scale study to rigorously examine predictive biomarker profile for metabolically healthy (without co-morbidities) versus unhealthy (with co-morbidities) excessive GWG and PPWR.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	UNIVERSITY OF CAPE TOWN	LOVERS WALK	CAPE TOWN				ZAF	International Research and Research Training	000	1	12/10/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF CAPE TOWN	LOVERS WALK	CAPE TOWN				ZAF	International Research and Research Training	000	1	8/21/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $113,048 )
2024	2024	UNIVERSITY OF CAPE TOWN	LOVERS WALK	CAPE TOWN				ZAF	International Research and Research Training	000	1	8/23/2024	NEW	$113,048
														Subtotal = $113,048

Grand Total All Awards = $113,048

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Metabolomic predictors of weight gain during pregnancy and the postpartum period in South African women living with HIV

Award Number: K43TW012887

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 09/01/2025

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