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Adapting an evidence-based intervention to improve HIV testing and PrEP uptake in Vietnam

Award Number: K43TW012850
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 03/11/2026
AWARD TERMINATION DATE: 03/28/2025

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Adapting an evidence-based intervention to improve HIV testing and PrEP uptake in Vietnam - PROJECT SUMMARY Young men vulnerable to HIV due to sexual behaviors are experiencing an ongoing HIV epidemic in Vietnam, with an HIV prevalence of 12%. However, HIV testing and pre-exposure prophylaxis (PrEP) use among this population remain low. To improve HIV testing and PrEP use, mobile health (mHealth) interventions hold great promise to reach young men in low- and middle-income countries. HealthMindr, an evidence-based mHealth intervention developed in the United States for men at high risk for HIV, is an ideal option for adaptation for young men in Vietnam. I propose to adapt this app and explore barriers and facilitators of implementing the app among this population. The specific aims are to (1) Adapt the HealthMindr app to improve HIV testing and PrEP uptake among young men at high risk for HIV in Vietnam; (2) Examine acceptability, feasibility and preliminary effectiveness of the adapted app among young men at high risk for HIV in Vietnam and (3) Explore barriers and facilitators of implementing the adapted app among young men at high risk for HIV in Vietnam. In Aim 1, theater testing will be conducted through focus group discussions with young men and key other stakeholders, including health officials, clinic staff and community-based organizations. Theater testing data will be used to refine the app for beta testing. During beta testing, a small group of young men at high risk for HIV will use the app for 30 days, then complete an online survey and an exit interview to rate the app’s usability, provide their perspectives of the app and report any other areas for improvement. App analytics will also be collected to understand whether and how the app is used. In Aim 2, the adapted app with be tested among young men at high risk for HIV through a randomized controlled design. Young men will be randomized into the intervention or control arm (1:1 ratio). The intervention arm will have full access to the app for 3 months, while the control group will receive standard-of-care HIV services. Key app features include HIV test planning, risk and PrEP eligibility assessment, ordering of free condoms and HIV test kits, information about PrEP, and PrEP provider and HIV testing locations. HIV testing and PrEP use will be assessed at baseline and 3 months and compared between groups. A mixed methods approach will be used to evaluate app acceptability and feasibility. Quantitative data on acceptability and feasibility will be collected through the 3-month online survey, while qualitative data will be collected through in-depth interviews with a subset of young men in the intervention arm and other key stakeholders. In Aim 3, through the same qualitative study as Aim 2, factors that influence the implementation of the app will be explored. Determinants from seven domains will be identified: condition, technology, value proposition, adopter system, health organization, wider system and embedding/adaption over time. This proposal will generate data for designing a full-scale hybrid type 1 effectiveness-implementation trial to test the adapted app and identify implementation strategies to address the barriers of app implementation in low- and middle-income countries.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $67,979 )
2026	2026	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	International Research and Research Training	000	2	12/10/2025	NON-COMPETING CONTINUATION	$67,979
2026	2026	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	International Research and Research Training	001	2	3/17/2026	TERMINATION	$0
														Subtotal = $67,979

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	International Research and Research Training	001	1	7/16/2025	OTHER REVISION	$0
2025	2024	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	International Research and Research Training	000	1	3/28/2025	TERMINATION	$0
2025	2024	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	International Research and Research Training	003	1	8/5/2025	OTHER REVISION	$0
2025	2024	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	International Research and Research Training	002	1	7/22/2025	OTHER REVISION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $66,427 )
2024	2024	HANOI MEDICAL UNIVERSITY	NO 1 TON THAT TUNG ST	TRUNG TU WARD HA NOI				VNM	International Research and Research Training	000	1	8/19/2024	NEW	$66,427
														Subtotal = $66,427

Grand Total All Awards = $134,406

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Adapting an evidence-based intervention to improve HIV testing and PrEP uptake in Vietnam

Award Number: K43TW012850

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 03/11/2026

AWARD TERMINATION DATE: 03/28/2025

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