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Microbiome profiling of non-healing filarial lymphedema wounds in Ghana.

Award Number: K43TW012795
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Microbiome profiling of non-healing filarial lymphedema wounds in Ghana. - Project Summary/Abstract This proposal presents a five-year research career development program focused on advancing the field of microbiome in non-healing filarial lymphedema wounds in Ghana. Lymphatic filariasis (LF), often referred to as 'hidden hunger,' is one such condition that demands our immediate attention and unwavering commitment. In the shadows of global health priorities, LF has quietly spread its roots across 72 countries, ensnaring over 120 million lives, primarily in regions where healthcare resources are scarce. This is even more dire among individuals with late-stage presentations such as lymphedema. Focused on addressing the challenges posed by empirical treatment approach in managing infection-related LF complications such as chronic non-healing filarial wounds, increasing prevalence of antibiotic- resistant strains, we seek to pursue molecular-focused research with the opportunities that this comprehensive career development program provides. Leveraging advanced technologies and the QIIME 2 platform, the project seeks to identify unique microbial signatures in lymphedema wounds and resistance patterns, contributing to improved healthcare outcomes in LMICs. This is aimed at understanding the dynamics of bacterial and fungal communities, exploring the interrelationship between the microbial profiles and the clinical outcomes, establishing a LF-specific genomic library, and developing predictive algorithms for monitoring wound healing progression in LF patients. Understanding for instance, the microbial dynamics of LF-related infective complications will challenge the current research and clinical practice paradigms as it will pave the way for more definitive healthcare strategies that will mark a significant departure from empirical treatments, offering the advantage of evidence-based, targeted interventions. This project will help generate substantial dataset that will guide the development of relevant policies and guidelines that will encourage the policy implementation such as antibiotic stewardship practices and evidence- based management thereby optimizing patient outcomes. Again, as part of the approaches toward achieving the program's goals, this career development research project also focuses on enhancing leadership skills, strengthening research capacity through mentorship, and collaboration to drive impactful research outcomes and contribute to the improvement of healthcare practices among filarial lymphedema patients in LMICs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $89,062 )
2025	2025	KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY	MAIN ADMIN BUILDING, PREMPEH II LINK	KUMASI				GHA	International Research and Research Training	000	2	8/11/2025	NON-COMPETING CONTINUATION	$89,062
														Subtotal = $89,062

Issue Date FY: 2024 ( Subtotal = $89,534 )
2024	2024	KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY	MAIN ADMIN BUILDING, PREMPEH II LINK	KUMASI				GHA	International Research and Research Training	000	1	8/6/2024	NEW	$89,534
														Subtotal = $89,534

Grand Total All Awards = $178,596

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Microbiome profiling of non-healing filarial lymphedema wounds in Ghana.

Award Number: K43TW012795

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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