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Genomic Epidemiology of Campylobacter in Poultry to Enable the Effective Control of Human Campylobacteriosis in a Middle Income Country

Award Number: K43TW012298
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Genomic Epidemiology of Campylobacter in Poultry to Enable the Effective Control of Human Campylobacteriosis in a Middle Income Country - PROJECT SUMMARY The zoonotic pathogen Campylobacter is among the principal etiologies of diarrhea in children living in low resource settings. Emergence of multi drug resistance against clinically relevant antimicrobials including fluroquinolones and macrolides make it a high-priority pathogen by the World Health Organization. However, the molecular epidemiology and ecology of this pathogen in low- and middle- income countries (LMICs) remains unresolved. This knowledge gap is especially evident in the pathogen’s main host: the chicken. Preliminary evidence suggests that there are sufficient genomic features to differentiate Campylobacter populations between small-scale and industrially scaled poultry. This K43 Emerging Global Leader career development award aims to study and compare the molecular epidemiology and ecology of MDR Campylobacteriosis in industrially and domestically reared poultry within a highly endemic setting. This will be achieved through i) the detailed study of genomic features of Campylobacter populations from backyard reared and industrially produced poultry, ii) the assessment of Campylobacter genomic determinants of multi-drug resistance in backyard reared and industrially produced poultry, and iii) the linkage of epidemiologic data of locally reported antibiotic exposures and genomic signals of drug resistance. The results from this study will critically contribute to the human source attribution models of disease being built in the study under which this project is nested (an ongoing pediatric cohort and nested case control studying the transmission dynamics of Campylobacter in the Peruvian Amazon). To fulfill these goals, an accomplished group of mentors will collectively provide mentorship and train the candidate, Dr. Francesca Schiaffino. Dr. Schiaffino proposes a career development plan that includes advanced methodological training in genomic analysis (through coursework, personalized training sessions and on-site scholarly rotations), publications, grantsmanship and continued training in responsible conduct of research within the context of global health. The main mentoring committee is composed of world-class experts in the field, including Dr. Margaret N. Kosek (infectious diseases, epidemiology), Dr. Carlos Shiva (veterinary microbiology, poultry science), Dr. Craig T. Parker (microbial genomics), Dr. Kerry Cooper (bacterial genomics and targeted metagenomic analysis), Dr. Samuel Sheppard and Dr. Ben Pascoe (Campylobacter ecology and evolution, source attribution studies), and Mrs, Maribel Paredes (community based participatory research, project management). Dr. Schiaffino’s career development plan has been sequentially designed with the objective of positioning her as an independent veterinary scientist and epidemiologist with expertise in bacterial genomics with the overall objective of improving human and animal health through safe and robust food systems.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $49,985 )
2025	2025	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	000	3	12/16/2024	SUPPLEMENT FOR EXPANSION	$49,985
														Subtotal = $49,985

Issue Date FY: 2024 ( Subtotal = $152,280 )
2024	2024	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	000	3	5/30/2024	NON-COMPETING CONTINUATION	$152,280
														Subtotal = $152,280

Issue Date FY: 2023 ( Subtotal = $152,280 )
2023	2023	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	000	2	6/12/2023	NON-COMPETING CONTINUATION	$152,280
														Subtotal = $152,280

Issue Date FY: 2022 ( Subtotal = $152,280 )
2022	2022	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430	LIMA	LIMA			PER	International Research and Research Training	000	1	8/2/2022	NEW	$152,280
														Subtotal = $152,280

Grand Total All Awards = $506,825

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Genomic Epidemiology of Campylobacter in Poultry to Enable the Effective Control of Human Campylobacteriosis in a Middle Income Country

Award Number: K43TW012298

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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