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Defining the biology of HIV-associated aggressive B-cell lymphoma in Southern Africa

Award Number: K43TW011986
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/27/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2023

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Defining the biology of HIV-associated aggressive B-cell lymphoma in Southern Africa - PROJECT SUMMARY ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma, also among people with HIV, and accounts for roughly one-third of all non-Hodgkin lymphoma (NHL) cases worldwide. The 2008 classification of DLBCL recognized germinal centre B-cell (GCB) and activated B-cell (ABC)/non-GCB subtypes, and also a group that was unclassifiable based on gene expression. More recently, two research groups have independently identified subtypes of DLBCL based on shared genomic aberrations. In both studies, these subtypes differ in respect to pathogenic mechanisms, clinical characteristics, and survival outcomes. Although these studies represent significant advances in our understanding of DLBCL from the US and Europe, there is much work still to be done in describing the genetic patterns of DLBCL in sub-Saharan Africa, especially in patients with HIV. Further understanding of genetic and transcriptional heterogeneity of these lymphomas could inform new diagnostic and treatment approaches that improve outcomes for patients. The scientific goal of this proposal is to establish a biologically informed taxonomy of HIV-associated DLBCL in South Africa. The specific aims are to: (1) Establish genetically and transcriptionally defined subtypes of HIV-associated DLBCL in South Africa; and (2) Establish clinicopathological features of HIV-associated DLBCL associated with these subsets. This proposal is responsive to areas of critical need in South Africa: research that is highly relevant to regional health priorities; and the career development of a local clinician-scientist. These studies also support the long-term goal of developing low-cost diagnostic strategies that guide the treatment of lymphoma in South Africa. The project PI, Dr Katherine Antel, is a clinical hematologist at the University of Cape Town with the career goal of independently conducting research that will improve outcomes for patients with lymphoma. Her PhD work showed that in South Africa there are numerous local obstacles to lymphoma diagnosis and, notably, that within this tuberculosis (TB)- endemic area, patients with lymphoma are at high risk of misdiagnosis with extrapulmonary TB. The diagnostic algorithm developed as part of her research has led to a shorter time-to-diagnosis of lymphoma at Groote Schuur Hospital. A comprehensive career development plan comprising structured activities and mentorship opportunities will enable Dr Antel to continue her career development as a physician-scientist by acquiring advanced skills in 1) next-generation sequencing; 2) bioinformatics; 3) biostatistical approaches for integrating genomics and clinical datasets; and 4) cellular and in vivo approaches to interrogate the effects of novel gene mutations. This K43 award will position her to build an independent program of research in lymphoma that drives innovative diagnostic and therapeutic approaches for patients in southern Africa.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$9,733 )
2024	2022	UNIVERSITY OF CAPE TOWN	LOVERS WALK	CAPE TOWN				ZAF	International Research and Research Training	000	2	11/28/2023	NON-COMPETING CONTINUATION	-$9,733
														Subtotal = -$9,733

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF CAPE TOWN	LOVERS WALK	CAPE TOWN				ZAF	International Research and Research Training	000	2	5/30/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $104,575 )
2022	2022	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH				ZAF	International Research and Research Training	000	2	5/5/2022	NON-COMPETING CONTINUATION	$104,575
														Subtotal = $104,575

Issue Date FY: 2021 ( Subtotal = $110,505 )
2021	2021	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH				ZAF	International Research and Research Training	000	1	8/31/2021	NEW	$110,505
														Subtotal = $110,505

Grand Total All Awards = $205,347

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Defining the biology of HIV-associated aggressive B-cell lymphoma in Southern Africa

Award Number: K43TW011986

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/27/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2023

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