Tuesday, September 16, 2025 9/16/2025

COMParative ASSessment of p16/Ki-67 DUal Staining Technology in women living with HIV (COMPASS-DUST study)

Award Number: K43TW011930
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/20/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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COMParative ASSessment of p16/Ki-67 DUal Staining Technology in women living with HIV (COMPASS-DUST study) - Project Summary This application presents a five-year career development and research program for an early career investigator from Nigeria. The candidate, Kehinde Okunade, is a 2018 Fogarty fellow through the HBNU FIC D43 Training Program and also a Senior Lecturer in Obstetrics and Gynecology at the College of Medicine of the University of Lagos in Nigeria. The goals of his application are to use the protected time provided through the program to (1) Build and strengthen mentoring relationships and skills transfer through regular interactions with mentors and co-mentors; (2) Acquire experiential skills in clinical epidemiologic research and be able to translate this to public health practice (3) Conduct the rigorous research proposed in the application; (4) Acquire skills in the design and conduct of end-to-end clinical trials; (5) Establish research collaboration network and effectively coordinate multidisciplinary research projects, and (6) Be able to write, secure, and manage grants to conduct studies as well as write manuscripts for publication in high-impact journals. The proposed research in the FIC K43 application, “COMParative ASSessment of p16/Ki-67 DUal Staining Technology in women living with HIV (COMPASS-DUST)” is the first in sub-Saharan Africa (sSA) that aims to evaluate the performance of p16/Ki-67 dual staining technology (DUST) in cervical cancer screening among women living with HIV (WLHIV). In Aim 1 and 2, using an intra-participant comparative study design, we will enrol n=300 sexually active WLHIV aged 25–65 years at two accredited adult HIV treatment centres in Lagos, Nigeria to compare the performance of DUST to the currently used screening methods (Pap smear, hr-HPV DNA, or VIA testing) in detecting high-grade cervical intraepithelial neoplasia (CIN2/3). In Aim 3, we will use a prospective cohort study design to enrol WLHIV (n=60) who are diagnosed as having low-grade CIN (CIN1) for a 6-monthly follow-up for 2 years to detect persistent CIN1 and progression of CIN1 to CIN2/3. The findings of this study will be of great public health significance for 2 reasons. First, they may provide evidence of the existence of a better performance screening method for the primary and triage detection of CIN2/3 in WLHIV. Secondly, we may demonstrate that this high-performance test can improve the long-term predictive accuracy of screening by extending the intervals between evaluations and thus decrease the overall cost and increase screening uptake in WLHIV. This application will build on the candidate’s background experience and the expertise of his team of mentors and co-mentors in Nigeria and the US to achieve the training and research goals of this program. In the long- term, the proposed research and training activities will provide the candidate with a unique set of experiential skills that will enable him to transition to independence as a physician-scientist.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $102,477 )
2025	2025	COLLEGE OF MEDICINE, UNIVERSITY OF LAGOS	IDI-ARABA	LAGOS				NGA	International Research and Research Training	000	4	6/30/2025	NON-COMPETING CONTINUATION	$102,477
														Subtotal = $102,477

Issue Date FY: 2024 ( Subtotal = $100,193 )
2024	2024	COLLEGE OF MEDICINE, UNIVERSITY OF LAGOS	IDI-ARABA	LAGOS				NGA	International Research and Research Training	000	3	7/2/2024	NON-COMPETING CONTINUATION	$100,193
														Subtotal = $100,193

Issue Date FY: 2023 ( Subtotal = $98,004 )
2023	2023	COLLEGE OF MEDICINE, UNIVERSITY OF LAGOS	IDI-ARABA	LAGOS				NGA	International Research and Research Training	001	2	6/12/2023	NON-COMPETING CONTINUATION	$98,004
2023	2022	COLLEGE OF MEDICINE, UNIVERSITY OF LAGOS	IDI-ARABA	LAGOS				NGA	International Research and Research Training	000	1	11/18/2022	NEW	$0
														Subtotal = $98,004

Issue Date FY: 2022 ( Subtotal = $95,239 )
2022	2022	COLLEGE OF MEDICINE, UNIVERSITY OF LAGOS	IDI-ARABA	LAGOS				NGA	International Research and Research Training	001	1	8/9/2022	NEW	$0
2022	2022	COLLEGE OF MEDICINE, UNIVERSITY OF LAGOS	IDI-ARABA	LAGOS				NGA	International Research and Research Training	000	1	7/21/2022	NEW	$95,239
														Subtotal = $95,239

Grand Total All Awards = $395,913

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COMParative ASSessment of p16/Ki-67 DUal Staining Technology in women living with HIV (COMPASS-DUST study)

Award Number: K43TW011930

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/20/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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