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Host defense against Shigella flexneri

Award Number: K43TW011441
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/27/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Host defense against Shigella flexneri - Project Summary Our Objective: To understand the host response to S. flexneri infection in developing potential host directed therapeutics. Hypothesis: Host genes and cellular processes are essential for efficient colonization and dissemination of S. flexneri in the human colon. These genes and cell processes can be discovered by comparing colonic biopsies during acute shigellosis to convalescence. Significance: Approximately 165 million cases of shigellosis are annually reported in low-income countries, with at least 1 million of these cases resulting in death, especially in children under five years of age (5). Very recently, Shigella ranked the highest among the overall pathogen burden, with a particularly high incidence in the second year of life (10). As is well known to CDC, multidrug resistant Shigella infections are a “serious” threat (18). Currently, no effective vaccine with the ability to confer adequate protection against the many different serotypes of Shigella has been developed. Investigators: Dr. Zannatun Noor is an early career research scientist from Bangladesh and seeking a mentored research career development award. She will conduct the study under supervision of Bangladesh mentor Dr. Rashidul Haque at icddr, b and USA mentor Dr. William A. Petri at University of Virginia. Both mentors are working with collaboration for more than two decades and have successfully completed different studies. Innovation: Determine gene expression and cellular infiltration to identify the host immune response is ground-breaking in Shigellosis. We will conduct RNAseq and CyTOF of colon biopsies to determine host gene expression and cellular infiltration respectively. Approach: To test our hypothesis, our specific aims are- 1) Systematically determine and characterize colonic gene expression profiles in response to S. flexneri infection. 2) Determine the identity of infiltrating immune cells in the colon during S. flexneri infection vs convalescence. Environment: Key to success of the study are the experienced mentors and highly motivated candidate who is seeking for the necessary training, practical experience, and knowledge to become a leading independent investigator in implementing child health interventions to reduce burden of infectious diseases in Low and Middle-Income Countries. Mentors are complementary expertise, like US mentor at the University of Virginia in immunology and in advance technology and LMIC mentor at icddr, b in clinical investigation. Both the host institute at LMIC and US institute have strong commitment to the candidate and her proposed career development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA				BGD	International Research and Research Training	000	5	3/22/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $74,649 )
2023	2023	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA			BGD	International Research and Research Training	000	5	3/20/2023	NON-COMPETING CONTINUATION	$74,649
														Subtotal = $74,649

Issue Date FY: 2022 ( Subtotal = $70,918 )
2022	2022	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA			BGD	International Research and Research Training	000	4	4/4/2022	NON-COMPETING CONTINUATION	$70,918
														Subtotal = $70,918

Issue Date FY: 2021 ( Subtotal = $67,175 )
2021	2021	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA			BGD	International Research and Research Training	000	3	6/8/2021	NON-COMPETING CONTINUATION	$67,175
														Subtotal = $67,175

Issue Date FY: 2020 ( Subtotal = $64,221 )
2020	2020	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA	1212		BGD	International Research and Research Training	001	2	4/28/2020	NON-COMPETING CONTINUATION	$64,221
2020	2019	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA	1212		BGD	International Research and Research Training	000	1	4/28/2020	NEW	$0
														Subtotal = $64,221

Issue Date FY: 2019 ( Subtotal = $61,227 )
2019	2019	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH	68, SHAHEED TAJUDDIN AHMED SARANI	DHAKA	DHAKA	1212		BGD	International Research and Research Training	000	1	7/27/2019	NEW	$61,227
														Subtotal = $61,227

Grand Total All Awards = $338,190

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Host defense against Shigella flexneri

Award Number: K43TW011441

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/27/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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