Tuesday, July 1, 2025 7/1/2025

Vaginal Microbiome in Cervical Intraepithelial Neoplasia and Cancer

Award Number: K43TW011416
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2024

Group Awards By:

View Award Description

Vaginal Microbiome in Cervical Intraepithelial Neoplasia and Cancer - Abstract This K43 application seeks to advance the research and career training of Dr. Jonah Musa, an Associate professor in obstetrics and gynecology at the University of Jos, Nigeria. Dr. Musa’s career goal is focused on improving cervical cancer outcomes through prevention and early detection and treatment of precancerous conditions of the cervix. The focus on prevention and early detection is novel in Nigeria and other Low and Middle-Income Countries (LMICs) where organized cervical cancer screening services are lacking with the consequence of high incidence and mortality due to late diagnosis. In Nigeria, over 53 million women are at risk of developing cervical cancer, and available cervical cancer screening coverage is less than 9% of the population at risk. The title of this proposed research, “Vaginal Microbiome Associated with Cervical Intraepithelial Neoplasia and Cancer”, seeks to identify the microbiome community state types, inflammatory biomarkers and epigenetic markers in cervical intraepithelial neoplasia (CIN) and in invasive cervical cancer (ICC). In addition, we will study the longitudinal changes in these biomarkers during progression from low grades CIN to high grades CIN and ICC over time. This project is of great significance since the viruses attributed to ICC are commonly acquired through high-risk sexual behavior, and our understanding of the biomarkers associated with the HR-HPV found in high grades precancerous stages of the cervix and ICC could provide evidence for developing modifiable behavioral and therapeutic interventions for improved cervical cancer outcomes at the population levels, and also translate findings to development of early diagnostic markers for identifying women with high grades CIN in our screening population. Candidate’s background: I’m specialty trained in general obstetrics and gynecology in Nigeria, and have completed graduate level training and earned a Master of Science and Doctor of Philosophy degrees at Northwestern University. Currently working as co-investigator on an ongoing U54 NCI funded epigenetics of cervical cancer project in Jos Nigeria. Therefore, my short-term goal for this K43 is to acquire further theoretical and more importantly, experiential skills to be able to conduct microbiome research and apply quantitative methodology in understanding microbiome and molecular data more broadly, to contribute to the understanding of cervical cancer prevention in Nigeria and globally. In the long-term, I want to generate sufficient pilot data in this field of research that will enable me to successfully compete for an R01 funding and gain research independence from my team of mentors. Research: This proposal has 3 inter-related aims: Aim 1: Characterize vaginal microbiome and inflammatory biomarkers in the spectrum of cervical precancer and invasive cervical cancer; Aim 2: Determine longitudinal changes in vaginal microbiome and inflammatory biomarkers in women with low- grade CIN progressing to high-grades CIN and cancer over time; Aim 3: Determine epidemiologic predictors of microbiome, inflammatory and epigenetic biomarkers associated with high-grades CIN and ICC.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF JOS	BAUCHI ROAD CAMPUS	JOS				NGA	International Research and Research Training	000	4	7/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF JOS	BAUCHI ROAD CAMPUS	JOS	PLATEAU			NGA	International Research and Research Training	000	4	6/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $92,988 )
2022	2022	UNIVERSITY OF JOS	BAUCHI ROAD CAMPUS	JOS	PLATEAU			NGA	International Research and Research Training	000	4	4/4/2022	NON-COMPETING CONTINUATION	$92,988
														Subtotal = $92,988

Issue Date FY: 2021 ( Subtotal = $92,988 )
2021	2021	UNIVERSITY OF JOS	BAUCHI ROAD CAMPUS JOS	JOS, PLATEAU				NGA	International Research and Research Training	001	3	6/11/2021	NON-COMPETING CONTINUATION	$92,988
2021	2020	UNIVERSITY OF JOS	BAUCHI ROAD CAMPUS JOS	JOS, PLATEAU				NGA	International Research and Research Training	000	2	11/6/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $92,988

Issue Date FY: 2020 ( Subtotal = $92,988 )
2020	2020	UNIVERSITY OF JOS	BAUCHI ROAD CAMPUS JOS	JOS, PLATEAU		930001		NGA	International Research and Research Training	002	2	5/6/2020	NON-COMPETING CONTINUATION	$92,988
2020	2019	UNIVERSITY OF JOS	BAUCHI ROAD CAMPUS JOS	JOS, PLATEAU		930001		NGA	International Research and Research Training	001	1	5/1/2020	NEW	$0
2020	2019	UNIVERSITY OF JOS	BAUCHI ROAD CAMPUS JOS	JOS, PLATEAU		930001		NGA	International Research and Research Training	000	1	10/31/2019	NEW	$0
														Subtotal = $92,988

Issue Date FY: 2019 ( Subtotal = $92,988 )
2019	2019	UNIVERSITY OF JOS	BAUCHI ROAD CAMPUS JOS	JOS, PLATEAU		930001		NGA	International Research and Research Training	000	1	9/20/2019	NEW	$92,988
														Subtotal = $92,988

Grand Total All Awards = $371,952

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Vaginal Microbiome in Cervical Intraepithelial Neoplasia and Cancer

Award Number: K43TW011416

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2024

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer