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PRENATAL FINE PARTICULATE MATTER (PM2.5) AND POLYCYCLIC AROMATIC HYDROCARBON (PAH) EXPOSURES AND THEIR ASSOCIATION WITH BIRTHWEIGHT IN SOUTHERN INDIA

Award Number: K43TW011408
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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PRENATAL FINE PARTICULATE MATTER (PM2.5) AND POLYCYCLIC AROMATIC HYDROCARBON (PAH) EXPOSURES AND THEIR ASSOCIATION WITH BIRTHWEIGHT IN SOUTHERN INDIA - PROJECT SUMMARY / ABSTRACT Air pollution is a leading risk factor for the national disease burden in India, resulting in an estimated 1.17 million adult and 116,000 neonatal deaths in 2019. Ambient air pollution is increasing steadily across Indian megacities and nearly 100% of the population experience exposures to unsafe levels of fine particulate matter (PM2.5). Further, exposures to air toxics such as polycyclic aromatic hydrocarbons (PAHs) are likely to be widespread in urban India on account of ubiquity of sources and high volume of emissions, but exposures to air toxics remain poorly characterized. Impacts of air pollution on pregnant women and the developing fetus have tremendous implications for India where, the prevalence of low birth weight (LBW <2.5 kg birthweight) is already high (15 to 30% across states). Despite the ubiquity of health damaging PM2.5 and PAHs exposure and high prevalence of LBW, evidence linking these exposures to adverse pregnancy outcomes has been limited in India. To address this evidence gap, the study proposes to establish an urban cohort of 300 pregnant women in Chennai (a megacity in southern India) to examine pregnancy period exposures to PM2.5 and PAHs through personal monitoring and biomarker measurements and examine associations with birthweight. The proposed research builds on the extensive capacities at the host institution created through previous NIH supported projects. The study will recruit 300 pregnant women from outpatient clinics of Sri Ramachandra Hospital (applicants host institute), conduct 24-hour personal exposure measurements for PM2.5 and PAHs three times, once during each trimester using a wearable sampler and assess the oxidative potential of the PM2.5 fractions (PM-OP) by acellular assays and its relationship with PM2.5 and PAHs. Urinary levels of PAH metabolites (2- naphthol and 1-hydroxypyrene) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-OHdG), a biomarker of oxidative damage will be measured during each trimester and leukocyte telomere length (LTL) will be measured in cord blood. This will allow an evaluation of the individual and interactive associations between PM2.5, PAHs, PM-OP, urinary biomarkers (PAH metabolites and 8-OHdG) and telomere length. On a 100-person subset of the cohort, Fresh Air wristbands will be used to provide a measure of personal exposure to PAHs and will be evaluated with other measures of exposure and effect. Finally, the differential effects of PM2.5 and PAHs on term low-birth weight will be examined using single, two and multipollutant models. The study will strengthen the limited available exposure-response evidence for prenatal PM2.5 and PAH exposures and birthweight in India while also identifying potential vulnerable exposure windows. Career development activities will focus on advanced training in novel exposure assessment techniques, mass spectrometry-based techniques for biomarker analysis, regression analysis and multipollutant modeling. The increased investigator capacities will allow research beyond traditional PM mass-related health effects to address multiple environmental exposures that predominate in high exposure settings of urban India.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $61,636 )
2025	2025	SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH TRUST	NO 1, RAMACHANDRA NAGAR, PORUR	CHENNAI				IND	International Research and Research Training	000	4	7/25/2025	NON-COMPETING CONTINUATION	$61,636
														Subtotal = $61,636

Issue Date FY: 2024 ( Subtotal = $61,690 )
2024	2024	SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH TRUST	NO 1, RAMACHANDRA NAGAR, PORUR	CHENNAI				IND	International Research and Research Training	002	3	7/5/2024	NON-COMPETING CONTINUATION	$61,690
2024	2023	SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH TRUST	NO 1, RAMACHANDRA NAGAR, PORUR	CHENNAI				IND	International Research and Research Training	001	2	6/30/2024	NON-COMPETING CONTINUATION	$0
2024	2022	SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH TRUST	NO 1, RAMACHANDRA NAGAR, PORUR	CHENNAI				IND	International Research and Research Training	000	1	6/30/2024	NEW	$0
														Subtotal = $61,690

Issue Date FY: 2023 ( Subtotal = $61,765 )
2023	2023	SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH TRUST	NO 1, RAMACHANDRA NAGAR, PORUR	CHENNAI				IND	International Research and Research Training	001	2	6/30/2023	NON-COMPETING CONTINUATION	$61,765
2023	2022	SRI RAMACHANDRA MEDICAL COLLEGE AND RESEARCH INSTITUTE	1, RAMACHANDRA NAGAR	CHENNAI	TAMIL NADU			IND	International Research and Research Training	000	1	1/25/2023	NEW	$0
														Subtotal = $61,765

Issue Date FY: 2022 ( Subtotal = $61,690 )
2022	2022	SRI RAMACHANDRA MEDICAL COLLEGE AND RESEARCH INSTITUTE	1, RAMACHANDRA NAGAR	CHENNAI	TAMIL NADU			IND	International Research and Research Training	000	1	8/26/2022	NEW	$61,690
														Subtotal = $61,690

Grand Total All Awards = $246,781

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PRENATAL FINE PARTICULATE MATTER (PM2.5) AND POLYCYCLIC AROMATIC HYDROCARBON (PAH) EXPOSURES AND THEIR ASSOCIATION WITH BIRTHWEIGHT IN SOUTHERN INDIA

Award Number: K43TW011408

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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