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Biomarkers of Kaposi sarcoma recrudescence in Zambia

Award Number: K43TW011095
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2018
PERIOD OF PERFORMANCE END DATE: 10/31/2024

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Biomarkers of Kaposi sarcoma recrudescence in Zambia - ABSTRACT! Kaposi's sarcoma (KS) remains a highly prevalent malignancy in sub-Saharan Africa. Antiretroviral therapy (ART) and associated immune reconstitution has been correlated with a dramatic decline in the prevalence of KS in the US HIV infected population, but the impact of ART on KS in sub-Saharan Africa is less clear. In Zambia, even with the scale up of ART, KS remains the second most common cancer among adult men. For women, it is the third most common. Furthermore, treatment with chemotherapy plus ART is associated with recurrence rates of up to 50 percent in those that have a complete response. The overall objective of this application is to identify markers of epidemic KS recurrence and/or sustained remission in individuals that have an initial complete regression of lesions upon chemotherapy. We hypothesize that individuals with complete regression of all the lesions after chemotherapy will have differences in immunological and viral factors that have prognostic value for predicting KS re-development and/or sustained remission. We will test our hypothesis by longitudinally characterizing innate, humoral, and cellular immune responses against KSHV and comparing individuals that experience recurrence to those who do not. The identification of these biomarkers of outcome after remission will enable the selection of patients that require a longer follow up period, those that require maintenance therapy, and those that require second line chemotherapy. From our proposed activities, we will improve the long-term outcomes of HIV+ individuals that have had KS before and hence at high risk of recurrence. This will ultimately inform efforts to better understand KS pathogenesis and develop novel interventional strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	UNIVERSITY OF ZAMBIA	5005 GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	000	5	4/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF ZAMBIA	5005 GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	003	5	11/17/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2022	UNIVERSITY OF ZAMBIA	5005 GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	002	5	11/17/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2022	UNIVERSITY OF ZAMBIA	5005 GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	000	5	11/17/2023	NON-COMPETING CONTINUATION	$0
2024	2022	UNIVERSITY OF ZAMBIA	5005 GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	001	5	11/17/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $99,927 )
2023	2023	UNIVERSITY OF ZAMBIA	5005 GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	003	5	9/22/2023	SUPPLEMENT FOR EXPANSION	$99,927
2023	2022	UNIVERSITY OF ZAMBIA	GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	001	5	3/9/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	UNIVERSITY OF ZAMBIA	GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	000	5	3/9/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF ZAMBIA	GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	002	5	3/9/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $99,927

Issue Date FY: 2022 ( Subtotal = $220,969 )
2022	2022	UNIVERSITY OF ZAMBIA	GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	000	5	4/15/2022	NON-COMPETING CONTINUATION	$80,029
2022	2022	UNIVERSITY OF ZAMBIA	GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	001	5	9/13/2022	SUPPLEMENT FOR EXPANSION	$40,986
2022	2022	UNIVERSITY OF ZAMBIA	GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	002	5	9/16/2022	SUPPLEMENT FOR EXPANSION	$99,954
														Subtotal = $220,969

Issue Date FY: 2021 ( Subtotal = $160,348 )
2021	2021	UNIVERSITY OF ZAMBIA	GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	001	4	7/22/2021	SUPPLEMENT FOR EXPANSION	$80,319
2021	2021	UNIVERSITY OF ZAMBIA	GREAT EAST ROAD	LUSAKA				ZMB	International Research and Research Training	000	4	6/10/2021	NON-COMPETING CONTINUATION	$80,029
														Subtotal = $160,348

Issue Date FY: 2020 ( Subtotal = $80,029 )
2020	2020	UNIVERSITY OF ZAMBIA	GREAT EAST ROAD	LUSAKA		10101		ZMB	International Research and Research Training	000	3	4/30/2020	NON-COMPETING CONTINUATION	$80,029
														Subtotal = $80,029

Issue Date FY: 2019 ( Subtotal = $80,029 )
2019	2019	UNZA-SOCIAL DEVELOPMENT STUDI ES-DEMOGRAPHY DIVISION	GREAT EAST ROAD	LUSAKA		10101		ZMB	International Research and Research Training	000	2	4/19/2019	NON-COMPETING CONTINUATION	$80,029
														Subtotal = $80,029

Issue Date FY: 2018 ( Subtotal = $80,029 )
2018	2018	UNZA-SOCIAL DEVELOPMENT STUDI ES-DEMOGRAPHY DIVISION	GREAT EAST ROAD	LUSAKA		10101		ZMB	International Research and Research Training	001	1	9/20/2018	NEW	$0
2018	2018	UNZA-SOCIAL DEVELOPMENT STUDI ES-DEMOGRAPHY DIVISION	GREAT EAST ROAD	LUSAKA		10101		ZMB	International Research and Research Training	000	1	9/12/2018	NEW	$80,029
														Subtotal = $80,029

Grand Total All Awards = $721,331

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Biomarkers of Kaposi sarcoma recrudescence in Zambia

Award Number: K43TW011095

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2018

PERIOD OF PERFORMANCE END DATE: 10/31/2024

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