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Interdisciplinary and multi-level approach to estimate the disease burden and outcomes of childhood tuberculous meningitis.

Award Number: K43TW011006
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/05/2020
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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Interdisciplinary and multi-level approach to estimate the disease burden and outcomes of childhood tuberculous meningitis. - PROJECT SUMMARY Candidate: Dr. Karen du Preez has dedicated herself to a research career focused on improving health care for children in low and middle income countries (LMIC). Her overall career development goal is to become an independent clinician scientist with a comprehensive, interdisciplinary skill set and research network to efficiently answer high priority public health questions, and have the ability to translate research findings into meaningful policy and implementation changes to improve health care for children in South Africa, and globally. This overall goal is supported by three specific training aims: 1) To understand and apply specialized analytical skills to public health research, specifically disease estimation modelling techniques and spatial analytic methods; 2) To strengthen clinical, management and leadership expertise; and 3) To develop the ability to translate research into meaningful policy changes and implementation. Dr. du Preez has the full support of the Desmond Tutu TB Centre, an internationally recognized research center at Stellenbosch University, Cape Town, South Africa and has assembled a mentoring team highly experienced in all facets of pediatric TB research, and actively involved at both national and international level contributing to scientific steering committees and supporting pediatric TB program implementation. Research: The lack of reliable surveillance data for the disease burden and spectrum of pediatric tuberculosis (TB) is a challenge that limits our ability to appropriately manage the disease globally. TB meningitis (TBM) is a severe form of pediatric tuberculosis with very poor outcomes and often consequent lifelong neurological disability if not diagnosed and treated early. Very little childhood TBM surveillance data exist and the overall goal of this research is therefore to determine the burden, incidence and outcomes of childhood TBM at three levels: global, national (South Africa) and sub-national (Cape Town district), whilst identifying opportunities for prevention, earlier diagnosis and treatment. Mathematical modelling techniques will be used to estimate the global burden of childhood TBM disease and attributable mortality, by country and WHO region (Specific Aim 1). Routine TB surveillance data from South Africa, spanning 14 years (2004-2017), will be used to determine the spatiotemporal heterogeneity of the national disease burden and treatment outcomes of childhood TBM and identify population-level drivers of high burden locations and unfavorable outcomes (Specific Aim 2). Prospective, complementary surveillance strategies will identify all diagnosed and undiagnosed childhood TBM cases (<15 years) within the Cape Town health district over a 2-year period. All identified children will be eligible for enrolment in an observational cohort study that will collect data on diagnostic certainty, disease severity, comorbidities, outcomes and missed opportunities for both TB preventive therapy and earlier diagnosis, with the aim of informing earlier diagnosis (diagnostic algorithms) and targeted interventions for improved TBM prevention and care (Specific Aim 3).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $113,400 )
2024	2024	STELLENBOSCH UNIVERSITY	ADMINISTRATION BUILDING B, VICTORIA ST	STELLENBOSCH				ZAF	International Research and Research Training	000	5	12/25/2023	NON-COMPETING CONTINUATION	$113,400
														Subtotal = $113,400

Issue Date FY: 2023 ( Subtotal = $113,400 )
2023	2023	UNIVERSITEIT STELLENBOSCH	ADMINISTRATION BUILDING B, VICTORIA STREET	STELLENBOSCH				ZAF	International Research and Research Training	000	4	1/11/2023	NON-COMPETING CONTINUATION	$113,400
														Subtotal = $113,400

Issue Date FY: 2022 ( Subtotal = $109,032 )
2022	2022	UNIVERSITEIT STELLENBOSCH	ADMINISTRATION BUILDING B, VICTORIA STREET	STELLENBOSCH				ZAF	International Research and Research Training	000	3	1/10/2022	NON-COMPETING CONTINUATION	$109,032
														Subtotal = $109,032

Issue Date FY: 2021 ( Subtotal = $185,550 )
2021	2021	UNIVERSITEIT STELLENBOSCH	ADMINISTRATION BUILDING B, VICTORIA STREET	STELLENBOSCH				ZAF	International Research and Research Training	000	2	1/4/2021	NON-COMPETING CONTINUATION	$104,695
2021	2021	UNIVERSITEIT STELLENBOSCH	ADMINISTRATION BUILDING B, VICTORIA STREET	STELLENBOSCH				ZAF	International Research and Research Training	001	2	7/8/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITEIT STELLENBOSCH	ADMINISTRATION BUILDING B, VICTORIA STREET	STELLENBOSCH				ZAF	International Research and Research Training	002	2	7/22/2021	SUPPLEMENT FOR EXPANSION	$80,855
														Subtotal = $185,550

Issue Date FY: 2020 ( Subtotal = $100,603 )
2020	2020	UNIVERSITEIT STELLENBOSCH	VICTORIA STREET	STELLENBOSCH		7600		ZAF	International Research and Research Training	000	1	2/6/2020	NEW	$100,603
														Subtotal = $100,603

Grand Total All Awards = $621,985

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Interdisciplinary and multi-level approach to estimate the disease burden and outcomes of childhood tuberculous meningitis.

Award Number: K43TW011006

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/05/2020

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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