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Microbiota, Inflammation and Environmental Enteric Dysfunction (MiEED)

Award Number: K43TW010697
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/22/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2021

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Microbiota, Inflammation and Environmental Enteric Dysfunction (MiEED) - PROJECT SUMMARY In this application, I am requesting support from a career development award to support my research proposal titled “Microbiota, Inflammation and Environmental Enteric Dysfunction”. I will be undertaking this work with the mentorship of Dr. Jeffrey Gordon (Primary US mentor) at the Washington University, St Louis and Dr. Asad Ali (Primary LMIC mentor) at the Aga Khan University. This project builds on our existing studies of Environmental Enteric Dysfunction (EED), funded by the Bill and Melinda Gates Foundation. The current application aims to improve our understanding of the pathogenesis of EED by studying the evolution of gut microbial configuration in children who have clinical and histological evidence of EED. EED is common in children living in impoverished conditions with limited access to clean drinking water and sanitation. Histopathological changes of EED in small bowel mucosa include alteration in crypt to villous ratio along with lymphocytic infiltration of the villous epithelium and lamina propria. Although studies involving biopsies of small bowel mucosa are critical to study EED, these studies are uncommon because of logistic challenges involving performing endoscopies in field settings in LMICs. We have previously demonstrated in an ongoing BMGF funded study that we are able to safely obtain such biopsies, we now have a unique opportunity to study the relationship between gut microbiome evolution and EED in this cohort. The central hypothesis of the current application is that children with histological confirmation of EED have shared features of a bacterial community which is different from healthy controls and non-EED subjects, and that such changes in bacterial configuration are associated with enteric and systemic inflammation. For testing these hypotheses, evaluation of gut microbiome in healthy and stunted children will be carried out to identify the age discriminatory bacterial taxa in children with and without confirmation of EED. Dr. Gordon will be providing mentorship and experience in gut microbiome and microbiota analysis. Dr. Ali will provide the needed infrastructure of the field site and laboratory facilities, along with linking the microbiome analysis with clinical and histological outcomes of interest. The Aga Khan University is a leading regional research institute with multiple support systems for junior investigators which will be vital for my career transition as an independent scientist. My long term goal is to be the principal investigator of my own laboratory, focusing on studying the gut microbiome and its relationship with communicable and non-communicable diseases. I envision working on microbiota derived therapy for EED, and to find targets in the inflammatory pathways driven by changes in gut homeostasis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$14,601 )
2025	2019	AGA KHAN UNIVERSITY	STADIUM ROAD	KARACHI				PAK	International Research and Research Training	000	3	10/1/2024	NON-COMPETING CONTINUATION	-$14,601
														Subtotal = -$14,601

Issue Date FY: 2022 ( Subtotal = -$2,210 )
2022	2019	AGA KHAN UNIVERSITY	STADIUM ROAD	KARACHI				PAK	International Research and Research Training	002	3	6/29/2022	NON-COMPETING CONTINUATION	-$2,210
2022	2018	AGA KHAN UNIVERSITY	STADIUM ROAD	KARACHI				PAK	International Research and Research Training	001	2	6/29/2022	NON-COMPETING CONTINUATION	$0
2022	2017	AGA KHAN UNIVERSITY	STADIUM ROAD	KARACHI				PAK	International Research and Research Training	000	1	6/29/2022	NEW	$0
														Subtotal = -$2,210

Issue Date FY: 2021 ( Subtotal = -$14 )
2021	2019	AGA KHAN UNIVERSITY	OFFICE OF RESEARCH & GRADUATE STUDIES	KARACHI	KARACHI			PAK	International Research and Research Training	000	3	8/7/2021	NON-COMPETING CONTINUATION	-$14
														Subtotal = -$14

Issue Date FY: 2019 ( Subtotal = $64,933 )
2019	2019	AGA KHAN UNIVERSITY	OFFICE OF RESEARCH & GRADUATE STUDIES	KARACHI	KARACHI	74800		PAK	International Research and Research Training	000	3	4/17/2019	NON-COMPETING CONTINUATION	$64,933
														Subtotal = $64,933

Issue Date FY: 2018 ( Subtotal = $62,726 )
2018	2018	AGA KHAN UNIVERSITY HOSPITAL	STADIUM ROAD	KARACHI	KARACHI	74800		PAK	International Research and Research Training	000	2	6/5/2018	NON-COMPETING CONTINUATION	$62,726
														Subtotal = $62,726

Issue Date FY: 2017 ( Subtotal = $57,663 )
2017	2017	AGA KHAN UNIVERSITY HOSPITAL	STADIUM ROAD	KARACHI	KARACHI	74800		PAK	International Research and Research Training	000	1	8/24/2017	NEW	$57,663
														Subtotal = $57,663

Grand Total All Awards = $168,497

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Microbiota, Inflammation and Environmental Enteric Dysfunction (MiEED)

Award Number: K43TW010697

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/22/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2021

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