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Impact of malaria control interventions on the infectious reservoir, host immunity, and drug resistance in Uganda

Award Number: K43TW010365
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/22/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2023

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Impact of malaria control interventions on the infectious reservoir, host immunity, and drug resistance in Uganda - PROJECT SUMMARY/ABSTRACT This award will enable Dr. Joaniter Nankabirwa to investigate the impact of indoor residual spraying of insecticides (IRS) alone or in combination with mass drug administration (MDA, administration of a full doses of antimalarial treatment to an entire population irrespective of infection status) on the malaria infectious reservoir, host immunity, and drug resistance. The investigations will leverage data and samples from an on- going study in north-eastern Uganda comparing the community impacts of the interventions on malaria morbidity, mortality and transmission. This work will be undertaken with the guidance of an experienced team of mentors with strong expertise in epidemiology, immunology, molecular microbiology, and the design, implementation and analysis of clinical studies. Dr. Nankabirwa will further her career development by; 1) conducting the laboratory assays, 2) attending courses in clinical research, immunology, molecular microbiology, and data analysis, and 3) attending and presenting at international research conferences. This program will be critical in enabling Dr. Nankabirwa to establish a career as an independent malaria researcher in Uganda. In Uganda, malaria control progress has been slow and control gains have been fragile, with increases in parasite prevalence being observed following cessation of implementation of effective control interventions. For improved control and ultimately elimination, interventions should be designed to eliminate reservoirs of malaria parasites, including microscopic and sub-microscopic infections, and yet minimize both the loss of host immunity, and the development of resistance. The project proposed here will focus on the effects of IRS and MDA on sub-microscopic infections, host immunity and development of resistance, as well as the rebound effects of withdrawing the interventions on these markers. Understanding the impacts of these interventions will help to identify the optimal interventions to control and eliminate malaria in Uganda. We hypothesise that implementing IRS will lead to decreased prevalence of parasite infection, and adding MDA will be associated with a further decrease and sustained reduction in the prevalence, but with some loss of host immunity and increase in drug resistance compared to IRS alone. Findings from this study will guide decision making on how best to implement interventions to control and eliminate malaria in Uganda.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$19 )
2024	2021	INFECTIOUS DISEASES RESEARCH COLLABORATION	PLOT 2C NAKASERO HILL ROAD	KAMPALA				UGA	International Research and Research Training	000	5	1/24/2024	NON-COMPETING CONTINUATION	-$19
														Subtotal = -$19

Issue Date FY: 2021 ( Subtotal = $102,846 )
2021	2021	INFECTIOUS DISEASES RESEARCH COLLABORATION	PLOT 2C NAKASERO HILL ROAD	KAMPALA				UGA	International Research and Research Training	000	5	2/15/2021	NON-COMPETING CONTINUATION	$102,846
														Subtotal = $102,846

Issue Date FY: 2020 ( Subtotal = $102,910 )
2020	2020	INFECTIOUS DISEASES RESEARCH COLLABORATION	PLOT 2C NAKASERO HILL ROAD	KAMPALA				UGA	International Research and Research Training	000	4	3/7/2020	NON-COMPETING CONTINUATION	$102,910
														Subtotal = $102,910

Issue Date FY: 2019 ( Subtotal = $102,911 )
2019	2019	INFECTIOUS DISEASES RESEARCH COLLABORATION	PLOT 2C NAKASERO HILL ROAD	KAMPALA				UGA	International Research and Research Training	001	3	3/6/2019	NON-COMPETING CONTINUATION	$102,911
2019	2018	INFECTIOUS DISEASES RESEARCH COLLABORATION	PLOT 2C NAKASERO HILL ROAD	KAMPALA				UGA	International Research and Research Training	000	2	1/25/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $102,911

Issue Date FY: 2018 ( Subtotal = $102,903 )
2018	2018	INFECTIOUS DISEASES RESEARCH COLLABORATION	PLOT 2C NAKASERO HILL ROAD	KAMPALA				UGA	International Research and Research Training	000	2	5/7/2018	NON-COMPETING CONTINUATION	$102,903
														Subtotal = $102,903

Issue Date FY: 2017 ( Subtotal = $102,911 )
2017	2017	INFECTIOUS DISEASE RESEARCH C OLLABORATION	NEW MULAGO HILL	KAMPALA				UGA	International Research and Research Training	000	1	8/22/2017	NEW	$102,911
														Subtotal = $102,911

Grand Total All Awards = $514,462

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Impact of malaria control interventions on the infectious reservoir, host immunity, and drug resistance in Uganda

Award Number: K43TW010365

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/22/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2023

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