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ULTRA FAST AND SENSITIVE FLUORESCENCE-BASED CLINICAL ASSAYS

Award Number: K25EB007565
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2008
PERIOD OF PERFORMANCE END DATE: 06/30/2012

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ULTRA FAST AND SENSITIVE FLUORESCENCE-BASED CLINICAL ASSAYS - DESCRIPTION (provided by applicant): This Career Development Award application is for Dr. Kadir Asian, a researcher with an engineering background, who has great potential to make a career transition into an independent biomedical researcher. Dr. Asian has extensive research experience in nanotechnology, where he made contributions to the literature in the field of new preparation techniques for metal nanoparticle-based biosensing platforms and their subsequent applications in bioassays for protein and DMA detection. However, Dr. Asian has limited knowledge and experience in spectroscopy and biochemistry and no experience in cell culture and molecular biology techniques, which are essential tools for a biomedical researcher. The proposed CDA will introduce him to biology through advanced biology courses, departmental seminars, professional society meetings and workshops on molecular biology laboratory techniques. As a result of the proposed research, Dr. Asian will gain advanced biochemistry and molecular biology knowledge as well as corresponding laboratory techniques to identify and propose solutions to biomedical problems and perform and direct related research. In addition, Dr. Asian will also be trained in advanced spectroscopic techniques by Dr. Chris D. Geddes, a world renowned expert in fluorescence spectroscopy, and mentored in biological techniques by Dr. Joseph P.Y. Kao, an expert in nano- and cell biology. Proposed mentored training in spectroscopy and biology combined with his nanotechnology background will usher Dr. Asian into an independent career in biomedical research. The proposed research plan includes: a year of intense learning of spectroscopy, biology and biology laboratory techniques through courses and workshops (1/4th effort); the development of new biosensing platforms (consistent with his past research, a 1/4th effort); the development of two clinically relevant assays (2/4th effort) 1) cardiac marker assays for a clinical setting, and 2) p53 protein assays. Cardiovascular diseases and cancer are amongst the leading causes of mortality in developed countries. In this proposed research, new assays that can detect the relevant indicator proteins for the assessment of these diseases at very early stage will be developed for the potential downstream use in a clinical setting.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $163,592 )
2011	2011	MORGAN STATE UNIVERSTIY	HILLEN RD & COLD SPRING LANE	BALTIMORE	MD	21239	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	6/24/2011	NON-COMPETING CONTINUATION	$163,592
														Subtotal = $163,592

Issue Date FY: 2010 ( Subtotal = $160,085 )
2010	2010	MORGAN STATE UNIVERSTIY	HILLEN RD & COLD SPRING LANE	BALTIMORE	MD	21239	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	4	6/11/2010	NON-COMPETING CONTINUATION	$160,085
2010	2009	MORGAN STATE UNIVERSTIY	HILLEN RD & COLD SPRING LANE	BALTIMORE	MD	21239	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	10/15/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$123,504
2010	2009	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	10/15/2009	NON-COMPETING CONTINUATION	-$123,504
														Subtotal = $160,085

Issue Date FY: 2009 ( Subtotal = $155,520 )
2009	2009	MORGAN STATE UNIVERSTIY	HILLEN RD & COLD SPRING LANE	BALTIMORE	MD	21239	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	10/16/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$123,504
2009	2009	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	10/16/2009	NON-COMPETING CONTINUATION	-$123,504
2009	2009	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/26/2009	NON-COMPETING CONTINUATION	$155,520
														Subtotal = $155,520

Issue Date FY: 2008 ( Subtotal = $127,440 )
2008	2008	MARYLAND BIOTECHNOLOGY INSTITUTE	701 E PRATT STREET, SUITE 200	BALTIMORE	MD	21202	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/30/2008	NEW	$127,440
														Subtotal = $127,440

Grand Total All Awards = $606,637

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ULTRA FAST AND SENSITIVE FLUORESCENCE-BASED CLINICAL ASSAYS

Award Number: K25EB007565

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2008

PERIOD OF PERFORMANCE END DATE: 06/30/2012

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