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Automated Arthroscopic Partial Meniscectomy Patient Outcome Prediction using Deep Learning

Award Number: K25AR078928
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Automated Arthroscopic Partial Meniscectomy Patient Outcome Prediction using Deep Learning - PROJECT SUMMARY / ABSTRACT Mingrui Yang, PhD, is a biomedical imaging research scientist with quantitative background whose overarching goal is to conduct clinically oriented multidisciplinary research to improve the understanding, diagnosis, and treatment of musculoskeletal and other disorders through non-invasive medical imaging and quantitative methods such as machine learning. The study he proposes entitled Automated Arthroscopic Partial Meniscectomy using Deep Learning aims to develop automated systems for knee articular cartilage and meniscus segmentation and abnormality detection based on cutting-edge deep-learning models, as well as one- year patient outcome prediction after arthroscopic partial meniscectomy (APM) when physical therapy fails, utilizing MR imaging biomarkers identified by the deep-learning models. Candidate: Dr. Yang is a junior faculty member in the Program of Advanced Musculoskeletal Imaging (PAMI) of the Department of Biomedical Engineering at Cleveland Clinic. His training has been focused on quantitative sciences including mathematics, statistics, computer science, and technical development of magnetic resonance (MR) imaging. He aims to transition to clinically research in osteoarthritis (OA) and medical imaging. The proposed career development plan consists of four training goals to compel him toward an independent investigator: 1) Gain knowledge in knee OA and the role of APM in knee OA; 2) Gain an understanding of orthopaedic surgery, patient cohort, and clinical patient outcomes; 3) Gain an understanding of MR imaging biomarkers for knee OA and APM outcomes; 4) Gain expertise in clinical research. Environment: Dr. Yang and his primary mentor, Xiaojuan Li, PhD, have assembled a prominent team to guide Dr. Yang’s training and research plans. As a member of PAMI, he will work closely with researchers and clinicians in departments of Biomedical Engineering, Orthopaedics, and Diagnosis Imaging for his career development. Research: The proposed study will be carried out in three phases corresponding to the three aims: Aim 1 builds a deep learning system for automatic high-grade articular cartilage lesion detection on heterogeneous clinical knee MR images; Aim 2 develops an automated deep learning system to detect the presence of meniscal root tears on heterogeneous clinical knee MR images; Aim 3 utilizes the imaging finding(s) from the deep learning system(s) and patient demographics to predict the clinical outcomes after APM. Summary: The proposal will provide a novel, automated, and consistent tool for cartilage and meniscus segmentation and lesion detection on heterogeneous knee MR images collected from clinical routine practice. A prediction model using these imaging findings with patient demographics can help predict clinical outcomes for patients undergoing APM surgery. This proposal will also advance Dr. Yang’s career development toward an independent investigator in OA and biomedical imaging research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $133,512 )
2026	2026	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY	9500 EUCLID AVE.	CLEVELAND	OH	44195	CUYAHOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	7/7/2026	NON-COMPETING CONTINUATION	$133,512
														Subtotal = $133,512

Issue Date FY: 2025 ( Subtotal = $135,544 )
2025	2025	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY	9500 EUCLID AVE.	CLEVELAND	OH	44195	CUYAHOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	7/11/2025	NON-COMPETING CONTINUATION	$135,544
														Subtotal = $135,544

Issue Date FY: 2024 ( Subtotal = $135,890 )
2024	2024	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY	9500 EUCLID AVE.	CLEVELAND	OH	44195	CUYAHOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	6/3/2024	NON-COMPETING CONTINUATION	$135,890
														Subtotal = $135,890

Issue Date FY: 2023 ( Subtotal = $136,590 )
2023	2023	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE OF CASE WESTERN RESERVE UNIVERSITY	9500 EUCLID AVE.	CLEVELAND	OH	44195	CUYAHOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	7/13/2023	NON-COMPETING CONTINUATION	$136,590
														Subtotal = $136,590

Issue Date FY: 2022 ( Subtotal = $136,546 )
2022	2022	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU	9500 EUCLID AVE	CLEVELAND	OH	44195	CUYAHOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/1/2022	NEW	$136,546
														Subtotal = $136,546

Grand Total All Awards = $678,082

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Automated Arthroscopic Partial Meniscectomy Patient Outcome Prediction using Deep Learning

Award Number: K25AR078928

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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