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Mentoring and research to prepare oral PrEP delivery platforms for novel HIVprevention products

Award Number: K24MH123371
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Mentoring and research to prepare oral PrEP delivery platforms for novel HIVprevention products - ABSTRACT This is a career mentoring award to support Dr. Renee Heffron, Associate Professor at the University of Washington, with protected time to create a more structured approach to mentoring for herself and her colleagues and to increase the number of mentees that she has by at least 50%. Mentees will be among the next generation of researchers focused on HIV prevention, oral pre-exposure prophylaxis (PrEP), and novel PrEP products. Dr. Heffron, PhD, MPH is a clinical epidemiologist with advanced training in implementation science, behavioral science, and qualitative research. Dr. Heffron's mentoring style is grounded in the Social Cognitive Career Theory and includes emphasis on developing mentee's science identify. Mentees will work alongside Dr. Heffron on the newly proposed research in the K24 in the realm of implementation science as well as on her four ongoing NIH-funded studies in Uganda, Kenya, and South Africa. Mentoring aims are to: 1. Support and grow the next generation of US- and Africa-based leaders conducting patient-oriented research focused on delivery of oral PrEP and novel PrEP products through the provision of structured mentoring to a total of 20-40 (~5 new mentees/year) pre-doctoral students, postdoctoral fellows, junior faculty, and other junior investigators, including subsets who are female and identify as being from URG. 2. Establish and refine a structured mentoring program within the International Clinical Research Center, my research home within the University of Washington Department of Global Health. Newly proposed research provides opportunity for Dr. Heffron to grow her repertoire of work in implementation science, in order to identify best practices to integrate novel PrEP products into existing platforms for oral PrEP delivery by conducting 60 key informant qualitative interviews with experts developing novel PrEP products, PrEP program implementers, and end users who discontinued or rejected use of oral PrEP. A discrete choice experiment will be conducted with young women in Uganda to identify their preferences for different attributes of HIV prevention counseling and whether counseling scenarios would facilitate uptake of a PrEP product. Research specific aims are to: 1. Define a preliminary strategy for the integration of novel PrEP products (e.g., injectable Cabotegravir, Dapivirine intravaginal ring, TFV/LNG intravaginal ring) into existing oral PrEP programs by conducting qualitative interviews with experts in novel PrEP products, oral PrEP programs, and end users 2. Among young women who have discontinued or never initiated oral PrEP, to determine preferences for attributes of HIV prevention counseling that would support them to initiate and sustain use of a PrEP product


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $151,591 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	000	6	12/20/2024	NON-COMPETING CONTINUATION	$151,591
														Subtotal = $151,591

Issue Date FY: 2024 ( Subtotal = $146,342 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	000	5	12/28/2023	NON-COMPETING CONTINUATION	$146,342
														Subtotal = $146,342

Issue Date FY: 2023 ( Subtotal = $147,640 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	001	4	12/21/2022	NON-COMPETING CONTINUATION	$147,640
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	000	3	11/10/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	004	3	6/26/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$44,186
2023	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	003	2	6/26/2023	NON-COMPETING CONTINUATION	-$24,514
2023	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	002	1	6/26/2023	NEW	-$19,672
														Subtotal = $147,640

Issue Date FY: 2022 ( Subtotal = $151,590 )
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	001	2	9/14/2022	NON-COMPETING CONTINUATION	-$127,076
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	000	2	1/10/2022	NON-COMPETING CONTINUATION	$151,590
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	002	3	9/14/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$127,076
														Subtotal = $151,590

Issue Date FY: 2021 ( Subtotal = $151,591 )
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	000	1	12/25/2020	NEW	$151,591
														Subtotal = $151,591

Grand Total All Awards = $748,754

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Mentoring and research to prepare oral PrEP delivery platforms for novel HIVprevention products

Award Number: K24MH123371

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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