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Macrophage Pathogen Interactions in Regional Cystic Fibrosis Lung Inflammation

Award Number: K24HL150453
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Macrophage Pathogen Interactions in Regional Cystic Fibrosis Lung Inflammation - ABSTRACT The goal of this K24 is to provide support to allow Dr. Ashare to spend an additional 25% of her time mentoring junior physician scientists in patient-oriented research on inflammatory lung disease. This K24 will provide the opportunity for Dr. Ashare to expand her program in patient- oriented translational research, integrate new physician scientists and PhD scientists into her research program, and allow for additional protected time so she can mentor additional trainees. In addition, with the help of her senior advisory committee, she will also use this time to improve her own mentoring skills. This K24 describes two aims that involve patient-oriented translational research using primary lung macrophages obtained from human subjects. Each Aim will serve as an individual project for a new trainee. Aim1 exploits preliminary findings that macrophages isolated from different regions of the lung are metabolically different and will specifically investigate the impact of increased glycolytic metabolism in upper lobe macrophages on the generation of inflammation. This aim will also determine the role of succinate accumulation in the generation of the macrophage inflammatory response. Based upon our data demonstrating that there are phenotypic and genotypic differences in Pseudomonas aeruginosa isolates from different regions of the CF lung, Aim 2 will test the hypothesis that regional P. aeruginosa isolates differentially stimulate lung macrophage immune responses and exhibit different responses to extracellular succinate. These two independent but complementary aims will allow new trainees to pursue translational patient-oriented research projects that will lead to a greater understanding of host-pathogen interactions in the CF lung.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	DARTMOUTH-HITCHCOCK CLINIC	1 MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Lung Diseases Research	000	5	9/14/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $105,478 )
2024	2024	DARTMOUTH-HITCHCOCK CLINIC	1 MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Lung Diseases Research	000	5	4/24/2024	NON-COMPETING CONTINUATION	$105,478
														Subtotal = $105,478

Issue Date FY: 2023 ( Subtotal = $106,976 )
2023	2023	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Lung Diseases Research	000	4	5/19/2023	NON-COMPETING CONTINUATION	$106,976
														Subtotal = $106,976

Issue Date FY: 2022 ( Subtotal = $108,432 )
2022	2022	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Lung Diseases Research	000	3	5/30/2022	NON-COMPETING CONTINUATION	$108,432
														Subtotal = $108,432

Issue Date FY: 2021 ( Subtotal = $109,846 )
2021	2021	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Lung Diseases Research	000	2	5/13/2021	NON-COMPETING CONTINUATION	$109,846
														Subtotal = $109,846

Issue Date FY: 2020 ( Subtotal = $111,217 )
2020	2020	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Lung Diseases Research	000	1	7/1/2020	NEW	$111,217
														Subtotal = $111,217

Grand Total All Awards = $541,949

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Macrophage Pathogen Interactions in Regional Cystic Fibrosis Lung Inflammation

Award Number: K24HL150453

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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