Thursday, July 3, 2025 7/3/2025

Improving the efficiency of randomized trials of behavioral interventions for acute and chronic respiratory failure

Award Number: K24HL143289
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/05/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2023

Group Awards By:

View Award Description

Improving the efficiency of randomized trials of behavioral interventions for acute and chronic respiratory failure - The goal of this Midcareer Investigator Award in Patient-Oriented Research is to enhance the ability of Dr. Scott Halpern to mentor students, residents, post-doctoral fellows, and junior faculty in developing and testing behavioral economic interventions to prevent and improve outcomes following, acute and chronic respiratory failure. Patients with many forms of acute and chronic respiratory failure, such as acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD), respectively, are at high risk of death and suffer considerable short- and long-term impairments in quality of life and functioning. Behavioral interventions, including those informed by behavioral economic principles, hold great promise for preventing these conditions and improving outcomes. Yet the knowledge produced by randomized clinical trials (RCTs) of such interventions is limited due to impediments to patient accrual, patient-centered outcomes ascertainment, and the abilities of traditional analyses to determine which interventions work best for which patients. By leveraging the conceptual models, research infrastructures, and data collected in 5 of Dr. Halpern's ongoing or recently completed RCTs including 40,000 patients, Dr. Halpern and his mentees will develop and test ways to surmount each of these three barriers to producing greater knowledge on how to prevent and treat acute and chronic respiratory failure. First, they will conduct randomized trials of “nudges” to improve enrollment and retention in real RCTs. Second, they will learn and apply state-of-the-art natural language processing and machine learning techniques to enhance the ability to extract patient-centered outcomes from electronic health records, thereby identifying more efficient methods for outcome ascertainment in large, pragmatic RCTs. Third, they will learn and apply modern methods in causal inference and the detection of heterogeneous treatment effects to better understand how effective behavioral interventions are overall, how efficacious they would be if more patients adhered to them, and which interventions work best for which patients. These scientific aims will be completed within the context of a structured training program designed to improve Dr. Halpern's skills in mentoring junior patient-oriented researchers. Dr. Halpern has already successfully mentored more than two dozen patient-oriented researchers. However, by enabling him to reduce his clinical and administrative commitments, this award will increase the time he commits to mentoring, and will improve his mentoring skills by supporting didactic training in influence and leadership and “mentor-the-mentor” meetings with more senior mentors. The award will also enable him to develop a “Junior Faculty Visiting Professor Program in Pulmonary and Critical Care Medicine,” thereby enhancing opportunities for his and other established investigators' mentees to network with other leaders in the field, receive external feedback and mentorship, and gain the confidence that comes with speaking to less familiar audiences.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	5	1/31/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $127,030 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	7	6/25/2024	NON-COMPETING CONTINUATION	$127,030
														Subtotal = $127,030

Issue Date FY: 2023 ( Subtotal = $127,300 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	6	4/26/2023	COMPETING CONTINUATION	$127,300
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	001	6	5/3/2023	COMPETING CONTINUATION	$0
														Subtotal = $127,300

Issue Date FY: 2022 ( Subtotal = $117,171 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	5	7/1/2022	NON-COMPETING CONTINUATION	$117,171
														Subtotal = $117,171

Issue Date FY: 2021 ( Subtotal = $118,570 )
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	4	7/6/2021	NON-COMPETING CONTINUATION	$118,570
														Subtotal = $118,570

Issue Date FY: 2020 ( Subtotal = $119,199 )
2020	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	3	7/17/2020	NON-COMPETING CONTINUATION	$119,199
														Subtotal = $119,199

Issue Date FY: 2019 ( Subtotal = $119,704 )
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	2	7/3/2019	NON-COMPETING CONTINUATION	$119,704
														Subtotal = $119,704

Issue Date FY: 2018 ( Subtotal = $120,139 )
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	1	7/4/2018	NEW	$120,139
														Subtotal = $120,139

Grand Total All Awards = $849,113

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Improving the efficiency of randomized trials of behavioral interventions for acute and chronic respiratory failure

Award Number: K24HL143289

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/05/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer