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Sleep health in special populations

Award Number: K24HL143055
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/21/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Sleep health in special populations - PROJECT SUMMARY The goal of this renewal application is to provide support for mentoring of trainees and junior investigators in the areas of sleep disorders and sleep health among patient populations who are “at risk.” The applicant’s current research program focuses on treatment of sleep disorders in populations who have not been studied or who have achieved less benefit from current evidence-based interventions. This program provides rich opportunities for mentees to experience direct engagement in patient-oriented sleep research. Currently funded work focuses on veterans with comorbid insomnia disorder and post-traumatic stress disorder (PTSD) for whom standard cognitive-behavioral therapy for insomnia (CBT-I) is less acceptable and less efficacious than among individuals without PTSD. Based on emerging evidence that the theoretical underpinning and specific exercises of Acceptance and Commitment Therapy (ACT) present a viable approach to improving sleep when combined with evidence-based behavioral strategies, a novel ACT-based insomnia treatment, called Acceptance and the Behavioral Changes to Treat Insomnia (ABC-I) is being tested in a clinical trial. ABC-I combines core behavioral components (sleep restriction, stimulus control, sleep hygiene, relaxation) with ACT-based techniques will be evaluated in a randomized trial. Using a comparative effectiveness design (n=200 randomized to ABC-I or cognitive-behavioral therapy for insomnia (CBT-I)), the primary aims of the study are to evaluate the benefits of ABC-I in reducing insomnia severity (non-inferiority) and PTSD symptoms (superiority) as compared to CBT-I. Additional aims address potential mechanisms of change from before to after treatment and explore potential ancillary benefits in terms of reducing other symptoms. The proposed analytic plan will simultaneously address superiority of ABC-I over CBT-I for improving PTSD symptoms and non-inferiority of ABC-I compared to CBT-I for improving insomnia symptoms. In addition to other ongoing and recently-completed projects, the study provides rich opportunities for trainees to engage in all aspects of patient-oriented research on sleep disorders, including direct interaction with research participants and engagement with data analysis and dissemination of findings. The research environment at UCLA and VAGLAHS is rich with opportunities for learning and for collaborative mentoring in areas of sleep health and sleep disorders. Building upon activities during the prior K- 24 award, the applicant will engage in formal leadership training and engage the support of a Leadership Development Council.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $130,173 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	National Center on Sleep Disorders Research	002	8	8/12/2025	NON-COMPETING CONTINUATION	$130,173
2025	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	National Center on Sleep Disorders Research	001	6	2/19/2025	COMPETING CONTINUATION	$40,010
2025	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	National Center on Sleep Disorders Research	000	5	2/19/2025	NON-COMPETING CONTINUATION	-$40,010
														Subtotal = $130,173

Issue Date FY: 2024 ( Subtotal = $130,173 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	National Center on Sleep Disorders Research	000	7	7/31/2024	NON-COMPETING CONTINUATION	$130,173
														Subtotal = $130,173

Issue Date FY: 2023 ( Subtotal = $130,173 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	National Center on Sleep Disorders Research	000	6	8/21/2023	COMPETING CONTINUATION	$130,173
														Subtotal = $130,173

Issue Date FY: 2022 ( Subtotal = $101,503 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	National Center on Sleep Disorders Research	000	5	8/8/2022	NON-COMPETING CONTINUATION	$101,503
														Subtotal = $101,503

Issue Date FY: 2021 ( Subtotal = $101,503 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	National Center on Sleep Disorders Research	000	4	7/30/2021	NON-COMPETING CONTINUATION	$101,503
														Subtotal = $101,503

Issue Date FY: 2020 ( Subtotal = $101,503 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	National Center on Sleep Disorders Research	000	3	7/31/2020	NON-COMPETING CONTINUATION	$101,503
														Subtotal = $101,503

Issue Date FY: 2019 ( Subtotal = $101,503 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	National Center on Sleep Disorders Research	000	2	7/24/2019	NON-COMPETING CONTINUATION	$101,503
														Subtotal = $101,503

Issue Date FY: 2018 ( Subtotal = $101,503 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	National Center on Sleep Disorders Research	000	1	7/19/2018	NEW	$101,503
														Subtotal = $101,503

Grand Total All Awards = $898,034

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Sleep health in special populations

Award Number: K24HL143055

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/21/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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