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Patient-Oriented Research and Mentoring on Mechanisms of Human Disease Immunopathogenesis

Award Number: K24DA065777
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/15/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2031

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Patient-Oriented Research and Mentoring on Mechanisms of Human Disease Immunopathogenesis - ABSTRACT Dr. Jiang has 8 years of patient care experience as a physician in Infectious Diseases and 23 years of translational research experience in determining mechanisms of immunopathogenesis in several diseases (i.e., drug abuse, HIV, SLE, AD) using patient-derived samples. Her NIH R01s, patient-oriented projects, prove her success in conducting human studies. As a physician-scientist at the Medical University of South Carolina, she has put forth this K24 Mid-Career Development proposal dedicated to mentorship in patient-centric translational research. Mentorship is vital for the career development of junior faculty, particularly in addressing the urgent need to train the next generation of scientists focused on determining the mechanisms of disease immunopathogenesis, a condition significantly impacting patient health and quality of life. The candidate aims to expand the pool of patient-oriented researchers and team scientists specializing in drug use-associated immunopathogenesis, a field with a large gap, emphasizing innovative, evidence-based assessment methods and targeted interventions to prevent and reverse pathogenic outcomes. This research and career development will occur within a supportive mentorship framework, fostering early-career researchers in determining the mechanisms of disease pathogenesis. The primary objective is to determine immunophenotypes and immune perturbations in chronic drug users using standardized and reliable immunologic assessment methods developed by the candidate, alongside advanced statistical mapping techniques. A secondary objective is to establish and investigate the potential mechanisms of immunopathogenesis in chronic drug users. The long-term objective is to develop therapeutic strategies to prevent or reverse pathogenesis and benefit patient care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $147,037 )
2026	2026	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	1	7/8/2026	NEW	$147,037
														Subtotal = $147,037

Grand Total All Awards = $147,037

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Patient-Oriented Research and Mentoring on Mechanisms of Human Disease Immunopathogenesis

Award Number: K24DA065777

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/15/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2031

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