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Mentoring Patient-Oriented Research on Central Nervous System (CNS) Dysfunction in Individuals with HIV and Substance Use

Award Number: K24DA065491
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Mentoring Patient-Oriented Research on Central Nervous System (CNS) Dysfunction in Individuals with HIV and Substance Use - The overall goal of this K24 application is to provide protected time to enhance my capabilities and mentor the next generation of researchers in patient-oriented research (POR) on the intersection of substance use and HIV. Clinical research examining the combined effects of substance use and HIV is of significant public health concern. People with HIV (PWH) on antiretroviral therapy (ART) continue to experience persistent immune activation and inflammation that increases risk of central nervous system (CNS) dysfunction. Substance use is highly prevalent in PWH and linked to behaviors that increase risk for HIV transmission and may worsen HIV disease and clinical (e.g., neurobehavioral) outcomes. Methamphetamine (METH) and cannabis are two widely used substances by PWH with potentially opposing effects on the CNS. Estimates of their co-use reach up to 50%, though few clinical studies have investigated their interaction on CNS or health outcomes, and even fewer have investigated the underlying biological mechanisms. To address these gaps, the proposed K24 will support trainee integration into active NIH-funded studies of individuals with and without HIV and/or substance use. Under structured mentoring and Individual Development Plans, trainees will gain investigator-level training in study design and implementation, recruitment and informed consent, clinical and neurobehavioral assessment and interpretation, data and biospecimen quality assurance, multimodal data integration and analyses, professional development, and research dissemination. K24 research projects will leverage data collected from active, ongoing studies and retrospective assessments, which collect comprehensive neuromedical, laboratory, psychiatric, neurocognitive, and everyday functioning outcomes, to identify and characterize clinical-biological profiles of CNS dysfunction in HIV and substance use disorders. Mentees will benefit from the rich training environment of the HIV Neurobehavioral Research Program and the Center for Medicinal Cannabis Research (HNRP-CMCR), with access to infrastructure and a wealth of data and specimens collected by active and completed HIV and substance use focused NIDA-funded research projects. In addition to one-on-one structured training, mentees will also have opportunities through UCSD-wide seminars and UCSD’s NIDA-funded T32 Training in Research on Addictions and NeuroAIDS (for which I serve as MPI). My active studies are well suited to support POR research aimed at identifying clinical-biological profiles of CNS outcomes in HIV, METH, and cannabis with high potential for clinical translation. Research projects proposed in this K24 are designed to address critical gaps in the field that are high priorities for NIDA and OAR and to serve as platforms for mentored training. Trainees will be recruited and matched to these projects according to their career goals, prior experience, and commitment to POR. Through structured one-on-one, investigator-level training, this K24 will enable mentees to build the skills needed to establish independent clinical research programs while contributing to advances in this high-priority field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $192,930 )
2026	2026	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	1	4/27/2026	NEW	$192,930
														Subtotal = $192,930

Grand Total All Awards = $192,930

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Mentoring Patient-Oriented Research on Central Nervous System (CNS) Dysfunction in Individuals with HIV and Substance Use

Award Number: K24DA065491

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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