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Mentoring in Translational Research in Inflammatory Skin Disease

Award Number: K24AR087610
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/08/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2031

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Mentoring in Translational Research in Inflammatory Skin Disease - Project Summary Dr. Tamia Harris-Tryon is an Associate Professor in the Department of Dermatology at UT Southwestern Medical Center. She has established a successful and independent research program focused on elucidating mechanistically interactions between the immune system, the skin, and the microbes that colonize the skin surface. Her experiences as an active clinical dermatologist, basic science researcher, and mentor have positioned her to be an ideal candidate for the K24 Mentoring Career Development Award. Leveraging her basic science findings demonstrating that the immune system regulates androgen production in the skin and her passion for mentoring trainees and faculty, Dr. Harris-Tryon and her team developed a novel method to quantify skin hormones non-invasively at the skin surface and observed that the immune system regulates androgen production in skin cells (PNAS, 2021). Her unique observations and studies have moved the field forward and her research program has been supported by continuous funding from the NIH, first with a K08 and now with R01 funding. Her team is also sponsored by foundation support from the Dermatology Foundation and industry award. These works and support have paved the way for a translational research program focused on defining how androgen- antagonism could be leveraged as a therapeutic strategy for the treatment of inflammatory skin diseases. In this proposal, Dr. Harris-Tryon has designed a series of aims to apply translational patient-oriented research (POR) approaches to these research questions, therefore expanding her research program and advancing therapeutic approaches in dermatology. The K24 award will support Dr. Harris-Tryon’s scientific career activities by allowing her to engage in professional development via coursework/training and execution of novel projects that bolster her research program and support future independent funding by both Dr. Harris-Tryon and her mentees. In addition to supporting scientific career activities, the K24 award will directly allow Dr. Harris-Tryon to pursue mentorship/leadership training and enhance her ability to more deeply engage with specific mentees pursuing K and R01 awards and more broadly engage with all mentees in dermatology training. The overall scientific aims of this proposal are to: 1) Determine if elevations in androgen production in the affected skin of AD patients correlates with skin barrier dysfunction and disease severity and 2) Elucidate the influence of the FDA approved anti-androgen therapy, spironolactone, on skin androgen amounts and skin barrier function. Completion of these aims will elucidate how AR-signaling regulates phenotypes in the skin and provide a platform to bolster the ability of Dr. Harris-Tryon and her mentees to complete patient-oriented research. If our hypothesis is correct, androgens may represent a novel biomarker for AD. These experiments will also provide the scientific rationale for future trials testing the efficacy of anti-androgen therapies in the treatment of AD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $123,108 )
2026	2026	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	4/9/2026	NEW	$123,108
														Subtotal = $123,108

Grand Total All Awards = $123,108

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Mentoring in Translational Research in Inflammatory Skin Disease

Award Number: K24AR087610

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/08/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2031

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