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Mentoring the next generation of researchers in pediatric autoimmunity

Award Number: K24AR085177
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/20/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2029

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Mentoring the next generation of researchers in pediatric autoimmunity - Abstract Dr. Shaun Jackson, an established researcher and leader in the field of pediatric autoimmunity, seeks a K24 Mid-Career Investigator Award to expand his mentorship of junior scientists engaged in patient-oriented research (POR) at the interface between pediatric rheumatology and autoimmune kidney disease. Dr. Jackson’s long- term career goal is to build a translational research program dedicated towards uncovering disease mechanisms in pediatric autoimmunity and developing novel treatments for affected children. In addition, he aims to cultivate the next generation of basic researchers and physician-scientists dedicated to POR in pediatric inflammatory diseases. During the period of K24 support, Dr. Jackson’s mentees will enter a structured training program that incorporates individualized development plans (IDP), didactic coursework in the principles of POR, cutting-edge research experiences, mentorship in writing manuscripts and grant applications, and professional networking necessary to build a successful POR career. To support these mentorship goals, Dr. Jackson has developed a K24 Career Development Plan for himself that focuses on: 1) training in the regulatory aspects of POR in support of an expanded autoimmune kidney disease research program; 2) designing clinical trials of novel cell therapies for pediatric autoimmunity; and 3) developing leadership skills in POR. Dr. Jackson’s current and future mentees will have the opportunity to work on a diverse portfolio of funded and proposed research studies. These include mechanistic interrogation of humoral autoimmunity in patients with STAT1 gain-of-function syndrome (Project 1), using cutting-edge spatial transcriptomics to study kidney inflammation human lupus nephritis (Project 2), correlative studies in patients receiving B cell-directed chimeric antigen receptor (CAR) T cells (Project 3), and a new project centered on a rare and largely unstudied pediatric autoimmune kidney disease, Tubulointerstitial Nephritis and Uveitis (TINU) syndrome. This research experience and structured mentorship program will be executed within the dynamic and collaborative environment of the Seattle Children’s Research Institute (SCRI), the University of Washington School of Medicine (UWSOM), and the greater Seattle biomedical community, where state-of-the-art facilities and a vibrant research community provide an ideal setting for POR training.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $211,662 )
2026	2026	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	1/13/2026	NON-COMPETING CONTINUATION	$211,662
														Subtotal = $211,662

Issue Date FY: 2025 ( Subtotal = $212,574 )
2025	2025	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	1/19/2025	NEW	$212,574
														Subtotal = $212,574

Grand Total All Awards = $424,236

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Mentoring the next generation of researchers in pediatric autoimmunity

Award Number: K24AR085177

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/20/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2029

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