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Preventing the Transition from Acute to Chronic Musculoskeletal Pain in Adolescents after Surgery: The Role of Sleep

Award Number: K24AR080786
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Preventing the Transition from Acute to Chronic Musculoskeletal Pain in Adolescents after Surgery: The Role of Sleep - PROJECT SUMMARY Acute and chronic musculoskeletal (MSK) pain are important health concerns across the lifespan, and surgery is a chief inciting event for subsequent persistent pain. Eighty percent of adolescents undergoing major MSK surgery report severe acute pain, and 20% develop chronic postsurgical pain. Having chronic pain in childhood and adolescence increases risk for a continued negative trajectory of MSK pain and poor health outcomes in adulthood, contributing to the national pain crisis. This K24 award will provide critical support for Dr. Rabbitts, a NIAMS-supported Associate Professor of Anesthesiology and Pain Medicine at the University of Washington (UW). The candidate's programmatic research has focused on developing innovative methods to identify biopsychosocial contributors to acute and chronic pain following MSK surgery in adolescents. During the course of this award, she will complete currently supported research: R01AR073780 which aims to increase understanding of the transition from acute to chronic postsurgical pain and the causal mechanisms involved, and UH3HD102038 (HEAL clinical trial) which evaluates the effectiveness of an mHealth perioperative psychosocial intervention to reduce acute and chronic pain in adolescents undergoing major musculoskeletal surgery. The candidate will expand her interprofessional mentoring program to build a strong and diverse cohort of pain scientists equipped to develop and implement long-term solutions to the MSK pain crisis through prevention. This K24 will also allow extension of the candidate's perioperative research program through training in sleep methodologies and building new collaborations to forge a novel research direction focused on sleep. The specific aims of the two new research studies proposed are to: 1) test pain processing as a mediator in the relationship between adolescent sleep immediately following surgery and subsequent MSK pain at 2 months after spine surgery, and 2) to determine feasibility of peri-operative melatonin in youth undergoing MSK surgery. The four projects will provide mentees with rigorous methodological training in a broad range of pain research assessment and intervention methods. This will capitalize on the wealth of opportunities available at SCRI and UW to actively engage promising trainees in the candidate's role as a physician-scientist, including via the SCRI Pediatric Pain Research Postdoctoral Fellowship and the UW T32 Training Program in Anesthesiology and Perioperative Medicine Research. Release from clinical activities provided by this award will allow the candidate to expand mentees at the fellow level, while enhancing mentorship skills, to equip a new generation of pain researchers with necessary scientific and professional skills, resiliency, and commitment to pain science, to make a sustained impact on the pain crisis. The K24 will also accelerate the candidate's research momentum informing the Type II renewal of her R01 and a new U01 efficacy trial of perioperative melatonin, which will be critical to her career objectives to achieve a deep understanding of contributing mechanisms and intervening to prevent acute to chronic MSK pain transition.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $175,954 )
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	5	3/26/2026	NON-COMPETING CONTINUATION	$175,954
2026	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	12/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $175,954

Issue Date FY: 2025 ( Subtotal = $177,496 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	4	4/14/2025	NON-COMPETING CONTINUATION	$177,496
2025	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	11/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $177,496

Issue Date FY: 2024 ( Subtotal = $178,684 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	3/22/2024	NON-COMPETING CONTINUATION	$178,684
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	4/4/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $178,684

Issue Date FY: 2023 ( Subtotal = $179,728 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	2	8/3/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$179,728
2023	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	6/1/2023	NEW	$179,728
2023	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	8/2/2023	NEW	-$179,728
														Subtotal = $179,728

Grand Total All Awards = $711,862

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Preventing the Transition from Acute to Chronic Musculoskeletal Pain in Adolescents after Surgery: The Role of Sleep

Award Number: K24AR080786

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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